Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis
Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis
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DOI：
10.1016/s0169-5002(00)00181-1
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发表时间：
2001-02-01
期刊：
影响因子：
5.3
通讯作者：
Khuder, SA
中科院分区：
文献类型：
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作者：
Khuder, SA
尽管吸烟是肺癌的一个公认的危险因素，但不同的组织学类型之间的关联强度还不是很清楚。这项同行评议研究的荟萃分析是为了评估吸烟对主要组织学类型肺癌的影响。研究是通过MEDLINE和CANCERLIT淀粉确定的。总共确定了1970至1999年间发表的48项研究。使用固定和随机效应模型计算相对风险(OR)和95%可信区间(CI)的组合估计。按研究设计和性别进行了单独的分析。线性剂量-反应适合于报告吸烟强度和持续时间的研究。所有组织学类型的肺癌都与吸烟显著相关。鳞状细胞癌(SQC)和小细胞癌(SCLC)的相关性强于大细胞癌(LGC)和腺癌(ADC)。最大吸烟强度(每天吸烟30支以上)的合并OR从ADC的4.10(CI 3.16~5.31)到SCLC的18.3(CI 9.26~36.4)。吸烟时间最长(40年以上)的合并OR从ADC的3.80(CI 2.35~6.16)到SCLC的38.6(CI 11.9~125)。在女人身上。SQC和SCLC的合并OR高于男性。女性吸烟强度的剂量反应曲线更陡峭。这项研究的发现为吸烟与所有组织学类型：肺癌之间的因果关系提供了额外的证据。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
Although cigarette smoking is an established risk factor for lung cancer, the strength of association with different histologic types is not well understood. This meta-analyses of peer-reviewed studies was conducted to assess the effect of cigarette smoking on major histologic types of lung cancer. Studies were identified through MEDLINE and CANCERLIT starches. A total of 48 studies published between 1970 and 1999 were identified. Combined estimates of relative risks (OR) and 95% confidence intervals (CI) were calculated using fixed and random effect models. Separate analyses were conducted by study design and gender. A linear dose-response was fit to studies reporting data on intensity and duration of smoking. All histologic types of lung cancer were significantly associated with cigarette smoking. The association was stronger with squamous cell carcinoma (SQC) and small cell carcinoma (SCLC) than with large cell cancer (LGC) and adenocarcinoma (ADC). The combined OR for heaviest smoking intensity (30 + cigarettes per day ranged from 4.10 (CI 3.16-5.31) for ADC to 18.3 (CI 9.26-36.4) for SCLC. The combined OR for longest duration of smoking (40 + years) ranged from 3.80 (CI 2.35-6.16) For ADC to 38.6 (CI 11.9-125) fur SCLC. in women. the combined OR for SQC and SCLC were higher than those in men. The dose response curve for intensity of smoking was steeper in women. The findings of this study provide additional evidence fur a causal relationship between smoking and all histologic types: of lung cancer. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.