Effect of GaAIAs low-level laser therapy on the healing of human palate mucosa after connective tissue graft harvesting: randomized clinical trial
Effect of GaAIAs low-level laser therapy on the healing of human palate mucosa after connective tissue graft harvesting: randomized clinical trial
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DOI：
10.1007/s10103-014-1685-2
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发表时间：
2015-08-01
影响因子：
2.1
通讯作者：
Santamaria, Mauro Pedrine
中科院分区：
文献类型：
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作者：
Fernanandes Dias, Stephanie Botti;Alves Fonseca, Marcus Vinicius;Santamaria, Mauro Pedrine
在现有的治疗牙龈退缩的技术中，结缔组织移植(CTG)具有更好的可预见性和长期效果。然而，这项技术会在腭部引起并发症和不适，因为该部位的移植物被移除。本临床试验的目的是评估低强度激光治疗(LLLT)对CTG术后供体腭区愈合的影响。选择32例表现为颊向牙龈萎缩的患者，随机分为两组，一组接受LLLT照射(试验组)，另一组接受LLLT假照射(对照组)。用半导体激光(AsGaAl，660 nm)在术后即刻和隔日进行一次连续7d的检测。评估参数为伤口剩余面积(WRA)、瘢痕和组织比色法(TC)、组织厚度(TT)和术后不适感(D)。在基线和术后7、14、45、60和90天对这些参数进行评估。采用双向重复测量方差分析进行统计分析。试验组在第14天和第45天出现了统计上显著较小的伤口。所有患者手术部位均无瘢痕形成，比色法分析显示两组间差异无统计学意义(p>；0.05)。患者报告轻度至中度不适，止痛药用量较少。我们的结论是，LLLT照射可以加速腭部粘膜在去除结缔组织后的创面愈合(ClinicalTrial.org NCT02239042)。
Among the available techniques to treat gingival recession, connective tissue graft (CTG) presents more foreseeability and better results in the long term. However, this technique causes morbidity and discomfort in the palatine region due to graft removal at that site. The aim of this clinical trial was to evaluate the influence of low-level laser therapy (LLLT) on the healing of the donor palatine area after CTG. Thirty-two patients presenting buccal gingival recession were selected and randomly assigned to receive LLLT irradiation (test group) or LLLT sham (control group) in the palatine area after connective graft removal. A diode laser (AsGaAl, 660 nm) was applied to test the sites immediately after surgery and every other day for 7 days. The evaluated parameters were wound remaining area (WRA), scar and tissue colorimetry (TC), tissue thickness (TT), and postoperative discomfort (D). These parameters were evaluated at baseline and 7, 14, 45, 60, and 90 days after surgery. Two-way repeated measures ANOVA was used for analysis. The test group presented statistically significant smaller wounds at days 14 and 45. None of the patients presented a scar at the operated area, and colorimetry analysis revealed that there was no statistically significant difference between groups (p > 0.05). Patients reported mild to moderate discomfort, with low consumption of analgesic pills. We concluded that LLLT irradiation can accelerate wound healing on palatine mucosa after connective tissue removal for root coverage techniques (ClinicalTrial.org NCT02239042).