Eph and ephrin signaling in the development of the central auditory system.
Eph and ephrin signaling in the development of the central auditory system.
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DOI：
10.1002/dvdy.506
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发表时间：
2023-01
影响因子：
2.5
通讯作者：
Yu, Wei-Ming
中科院分区：
文献类型：
--
作者：
Krasewicz, Jakub;Yu, Wei-Ming
关键词：
声学通信关键依赖于对环境中各种声音刺激的强度、频率、时间和位置等信息的准确解释。为了满足这一需求，听觉系统不同水平的神经元沿着形成精确组织的神经回路。这些精确回路的组装需要多个发育过程的严格调节和协调。事实证明，几组轴突引导分子对于控制这些过程至关重要。其中，Eph受体家族及其肝配蛋白配体作为一组关键参与者出现。它们在听觉通路的多个水平上介导多种功能，包括轴突引导和靶向、地形图形成以及细胞迁移和组织图案形成。在这里，我们回顾我们目前的知识如何Eph和ephrin分子调节不同的过程中的发展和成熟的中央听觉回路。Eph/ephrin信号传导调节第八脑神经中枢投射的分离和图案化以及CN的色调图精确度。Eph/ephrin信号调节听觉脑干中声音定位回路的组装。Eph/ephrin信号调节下丘中的色调投射的形成。Eph/ephrin信号调节内侧膝状体和听觉皮层的频率调谐和轴突靶向。
Acoustic communication relies crucially on accurate interpretation of information about the intensity, frequency, timing, and location of diverse sound stimuli in the environment. To meet this demand, neurons along different levels of the auditory system form precisely organized neural circuits. The assembly of these precise circuits requires tight regulation and coordination of multiple developmental processes. Several groups of axon guidance molecules have proven critical in controlling these processes. Among them, the family of Eph receptors and their ephrin ligands emerge as one group of key players. They mediate diverse functions at multiple levels of the auditory pathway, including axon guidance and targeting, topographic map formation, as well as cell migration and tissue pattern formation. Here, we review our current knowledge of how Eph and ephrin molecules regulate different processes in the development and maturation of central auditory circuits. Eph/ephrin signaling regulates the segregation and patterning of eighth cranial nerve central projections and tonotopic map precision of the CN. Eph/ephrin signaling regulates the assembly of the sound localization circuit in the auditory brainstem. Eph/ephrin signaling regulates the formation of tonotopic projections in the inferior colliculus. Eph/ephrin signaling regulates frequency tuning and axon targeting in the medial geniculate body and auditory cortex.
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影响因子：
2.5
作者：
Hsieh, Candace Y.;Hong, Cindy T.;Cramer, Karina S.
通讯作者：
Cramer, Karina S.
影响因子：
2.5
作者：
Cramer, KS;Karam, SD;Rubel, EW
通讯作者：
Rubel, EW
影响因子：
5.3
作者：
Hsieh, Candace Y.;Nakamura, Paul A.;Cramer, Karina S.
通讯作者：
Cramer, Karina S.
影响因子：
3.6
作者：
Allen-Sharpley MR;Cramer KS
通讯作者：
Cramer KS
DOI：
10.1016/j.mcn.2018.07.002
发表时间：
2018-09
期刊：
Molecular and cellular neurosciences
影响因子：
--
作者：
Henderson NT;Dalva MB
通讯作者：
Dalva MB