Network Structure and Function in Parkinson's Disease
Network Structure and Function in Parkinson's Disease
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DOI：
10.1093/cercor/bhx267
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发表时间：
2018-12-01
期刊：
影响因子：
3.7
通讯作者：
Eidelberg, David
中科院分区：
文献类型：
--
作者：
Ko, Ji Hyun;Spetsieris, Phoebe G.;Eidelberg, David
与神经系统疾病相关的异常脑网络的结构和功能特性所知甚少。我们使用社会网络方法在4个独立的患者样本和实验性非人灵长类动物模型中表征帕金森病（PD）代谢地形的特性。PD网络表现出明显的特征。致密的、相互促进的功能连接将壳核、苍白球和丘脑连接起来，形成一个代谢活跃的核心。外周是由连接不太活跃的皮质区域的较弱连接形成的。值得注意的是，该网络包含一个独立的模块，由小脑、脑桥、额叶皮层和边缘区域中相互连接的代谢活跃节点定义。在帕金森人类和非人类灵长类动物模型中，小世界属性的夸大是疾病网络的一贯特征；多巴胺能治疗只能部分纠正这种异常。研究结果指出，与疾病相关的网络结构和功能改变是这种疾病中错误信息处理的基础。
Little is known of the structural and functional properties of abnormal brain networks associated with neurological disorders. We used a social network approach to characterize the properties of the Parkinson's disease (PD) metabolic topography in 4 independent patient samples and in an experimental non-human primate model. The PD network exhibited distinct features. Dense, mutually facilitating functional connections linked the putamen, globus pallidus, and thalamus to form a metabolically active core. The periphery was formed by weaker connections linking less active cortical regions. Notably, the network contained a separate module defined by interconnected, metabolically active nodes in the cerebellum, pons, frontal cortex, and limbic regions. Exaggeration of the small-world property was a consistent feature of disease networks in parkinsonian humans and in the non-human primate model; this abnormality was only partly corrected by dopaminergic treatment. The findings point to disease-related alterations in network structure and function as the basis for faulty information processing in this disorder.