Update on anti-saccharomyces cerevisiae antibodies., anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases:: Results of a multicenter study
Update on anti-saccharomyces cerevisiae antibodies., anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases:: Results of a multicenter study
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DOI：
10.3748/wjg.v13.i16.2312
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发表时间：
2007-04-28
影响因子：
4.3
通讯作者：
Humbel, R. L.
中科院分区：
文献类型：
--
作者：
Desplat-Jego, S.;Escande, A.;Humbel, R. L.
目的：抗酿酒酵母抗体（ASCA）、抗核相关抗中性粒细胞抗体（NANA）和胰腺外分泌抗体（PAB）是鉴别克罗恩病（CrD）和溃疡性结肠炎（UC）的血清学工具。与CrD一样，乳糜泻（CoD）是一种与（自身）抗体相关的炎症性肠病（IBD）。进行一项多中心研究，我们的主要目的是确定ASCA，NANA和PAB测试IBD诊断的儿童和成人的性能，其次，以评估这些标志物在CoD的患病率。方法：血清109例CrD，78例UC，45例CoD和50名健康献血员进行了回顾性研究。采用间接免疫荧光法（IIF）检测ASCA、NANA和PAB。结果：ASCA+/NANA-谱对CrD的阳性预测值为94.2%。ASCA的检测与更严重的CrD临床特征相关，并且疾病的治疗不影响其血清水平。ASCA阳性率为37.9%。PAB在36.7%的CrD和13.3%的CoD患者中被发现，并且除了与疾病的早期发作之外，与CrD的临床特征无关。15例CrD患者ASCA阴性，PAB阳性。结论：IIF检测到的ASCA和PAB是CrD的特异性标志物，尽管它们的存在并不能排除可能的活动性CoD。ASCA，NANA和PAB测试的组合提高了CrD免疫标志物的敏感性。在CrD过程中重复ASCA，NANA和PAB测试没有临床价值。(C)2007年，WJG出版社。All rights reserved.
AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn's disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD.METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF).RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD. PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive.CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. (C) 2007 The WJG Press. All rights reserved.