Dental Pulp Stem Cells and Current in vivo Approaches to Study Dental Pulp Stem Cells in Pulp Injury and Regeneration.
Dental Pulp Stem Cells and Current in vivo Approaches to Study Dental Pulp Stem Cells in Pulp Injury and Regeneration.
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DOI：
10.11005/jbm.2023.30.3.231
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发表时间：
2023-08
影响因子：
--
通讯作者：
Park, Dongsu
中科院分区：
文献类型：
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作者：
Yang, Dongwook;Solidum, Jea Giezl Niedo;Park, Dongsu
牙髓干细胞（DPSC）因其独特的特性以及在牙齿发育和再生方面的潜力而引起了牙科研究的极大兴趣。虽然有许多研究来定义其干细胞样特征和成骨分化功能，这些功能被认为是再生受损牙髓组织的理想候选者，但内源性 DPSC 如何响应牙髓损伤并提供新的牙本质形成细胞尚未在体内得到广泛研究。在这里，我们回顾了内源性 DPSC 的身份、功能和调节及其对牙髓损伤和再生的临床潜力的最新进展。此外，我们还讨论了新小鼠模型、成像技术的最新进展及其在分析 DPSC 在牙髓损伤和体内再生中的实际用途和局限性。
Dental pulp stem cells (DPSCs) have garnered significant interest in dental research for their unique characteristics and potential in tooth development and regeneration. While there were many studies to define their stem cell-like characteristics and osteogenic differentiation functions that are considered ideal candidates for regenerating damaged dental pulp tissue, how endogenous DPSCs respond to dental pulp injury and supply new dentin-forming cells has not been extensively investigated in vivo. Here, we review the recent progress in identity, function, and regulation of endogenous DPSCs and their clinical potential for pulp injury and regeneration. In addition, we discuss current advances in new mouse models, imaging techniques, and its practical uses and limitations in the analysis of DPSCs in pulp injury and regeneration in vivo.