Cardiovascular risks impact human brain N-acetylaspartate in regionally specific patterns
Cardiovascular risks impact human brain N-acetylaspartate in regionally specific patterns
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DOI：
10.1073/pnas.1907730116
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发表时间：
2019-12-10
影响因子：
11.1
通讯作者：
Hong, L. Elliot
中科院分区：
文献类型：
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作者：
Chiappelli, Joshua;Rowland, Laura M.;Hong, L. Elliot
心血管危险因素如血脂异常和高血压会增加白色病变和认知能力下降的风险。我们假设，白色物质水平的N-乙酰天冬氨酸（NAA），一种参与髓鞘脂质合成代谢途径的化学物质，可以作为一种生物标志物，跟踪心血管危险因素的影响白色物质出现临床变化之前。为了验证这一点，我们使用回波平面光谱成像（EPSI）测量了163名个体大脑中白色物质和灰质的NAA水平，并检查了区域NAA水平与心血管危险因素的关系，这些危险因素由Frachial心血管危险评分（FCVRS）指数表示。NAA与整个大脑的FCVRS呈强负相关，但在考虑年龄和性别后，这种关联主要见于白色物质区域，在丘脑、海马和扣带回中发现了额外的影响。FCVRS也与肌酸水平呈负相关，同样主要在白色物质中。结果表明，心血管风险与神经化学有关，主要是白色物质模式和一些皮质下和皮质灰质参与。NAA脑定位可以提供早期监测的潜在亚临床影响的心血管和代谢危险因素对大脑。
Cardiovascular risk factors such as dyslipidemia and hypertension increase the risk for white matter pathology and cognitive decline. We hypothesize that white matter levels of N-acetylaspartate (NAA), a chemical involved in the metabolic pathway for myelin lipid synthesis, could serve as a biomarker that tracks the influence of cardiovascular risk factors on white matter prior to emergence of clinical changes. To test this, we measured levels of NAA across white matter and gray matter in the brain using echo planar spectroscopic imaging (EPSI) in 163 individuals and examined the relationship of regional NAA levels and cardiovascular risk factors as indexed by the Framingham Cardiovascular Risk Score (FCVRS). NAA was strongly and negatively correlated with FCVRS across the brain, but, after accounting for age and sex, the association was found primarily in white matter regions, with additional effects found in the thalamus, hippocampus, and cingulate gyrus. FCVRS was also negatively correlated with creatine levels, again primarily in white matter. The results suggest that cardiovascular risks are related to neurochemistry with a predominantly white matter pattern and some subcortical and cortical gray matter involvement. NAA mapping of the brain may provide early surveillance for the potential subclinical impact of cardiovascular and metabolic risk factors on the brain.