HIV testing and linkage to ART following secondary distribution of HIV self-test kits to male partners of women living with HIV: a pilot randomized control trial in Mpumalanga, South Africa.
HIV testing and linkage to ART following secondary distribution of HIV self-test kits to male partners of women living with HIV: a pilot randomized control trial in Mpumalanga, South Africa.
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DOI：
10.1002/jia2.25937
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发表时间：
2022-06
影响因子：
6
通讯作者：
Dovel, Kathryn
中科院分区：
文献类型：
--
作者：
Joseph Davey, Dvora L.;Wall, Kristin M.;Naidoo, Nireshni;Naidoo, Dhirisha;Xaba, Gugu;Serao, Claire;Malone, Todd;Dovel, Kathryn
南非男子在艾滋病毒检测和治疗服务中的代表性不足。艾滋病毒携带者妇女(WLHIV)向其男性伴侣(即指数伴侣HIVST)二次分发口服艾滋病毒自检试剂盒可能会增加男性的检测和治疗，但研究不足。在2021年3月至7月期间，我们在1：1的随机对照试验中，评估了指标合作伙伴HIVST与护理标准(SOC)(基于男性设施的测试邀请)对男性测试的有效性。资格标准包括：WLHIV；≥18岁；在四个高密度农村诊所之一就诊；有可以使用的手机；以及自我报告有一个血清状态不明的主要男性伴侣。主要结果是WLHIV报告她的伴侣在登记后3个月内检测艾滋病毒的比例。我们招募了180名WLHIV患者，176人完成了终点线调查(平均年龄=35岁，15%怀孕，47%未婚或非同居)。在HIVST组，78%的男性伴侣被报告进行了艾滋病毒检测，而在SOC组，这一比例为55%(RR=1.41；95%CI=1.14-1.76)。在HIVST组，9名男子HIVST呈阳性(14%阳性)，6名经标准检测确认艾滋病毒阳性(67%)，所有这些人都开始接受抗逆转录病毒治疗(ART)，4名艾滋病毒阴性男子开始接触前预防(PrEP)(5%)。在SOC，6名男子被诊断出感染艾滋病毒(12%阳性)，100%开始抗逆转录病毒治疗，7名艾滋病毒阴性男子开始PrEP(16%)。据报告，在HIVST部门发生了一起亲密伴侣言语暴力事件。在我们的初步研究中，将HIVST二次分发给WLHIV的合作伙伴，对于改善南非农村男子的艾滋病毒检测是可以接受和有效的。需要采取干预措施，将反应性HIVST使用者与验证性检测和抗逆转录病毒疗法联系起来。
South African men are underrepresented in HIV testing and treatment services. Secondary distribution of oral HIV self‐test (HIVST) kits by women living with HIV (WLHIV) to their male partners (i.e. index partner HIVST) may increase men's testing and treatment but has been understudied. Between March and July 2021, we evaluated the effectiveness of index partner HIVST versus the standard of care (SOC) (invitations for men's facility‐based testing) on men's testing in a 1:1 randomized control trial. Eligibility criteria included: WLHIV; ≥18 years of age; attending one of four high‐density rural clinics; have a working cell phone; and self‐reported having a primary male partner of unknown serostatus. The primary outcome was the proportion of WLHIV reporting that her partner tested for HIV within 3 months after enrolment. We enrolled 180 WLHIV and 176 completed an endline survey (mean age = 35 years, 15% pregnant, 47% unmarried or non‐cohabiting). In the HIVST arm, 78% of male partners were reported to have tested for HIV versus 55% in SOC (RR = 1.41; 95% CI = 1.14–1.76). In the HIVST arm, nine men were reactive with HIVST (14% positivity), six were confirmed HIV positive with standard testing (67%) and all of those started antiretroviral therapy (ART), and four HIV‐negative men started pre‐exposure prophylaxis (PrEP) (5%). In SOC, six men were diagnosed with HIV (12% positivity), 100% started ART and seven HIV‐negative men started PrEP (16%). One case of verbal intimate partner violence was reported in the HIVST arm. Secondary distribution of HIVST to partners of WLHIV was acceptable and effective for improving HIV testing among men in rural South Africa in our pilot study. Interventions are needed to link reactive HIVST users to confirmatory testing and ART.
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影响因子：
8.1
作者：
Indravudh PP;Fielding K;Chilongosi R;Nzawa R;Neuman M;Kumwenda MK;Nyirenda R;Johnson CC;Taegtmeyer M;Desmond N;Hatzold K;Corbett EL
通讯作者：
Corbett EL
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3.1
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3.3
作者：
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Peters, Remco P. H.