Antielastin autoimmunity in tobacco smoking-induced emphysema
Antielastin autoimmunity in tobacco smoking-induced emphysema
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DOI：
10.1038/nm1583
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发表时间：
2007-05-01
期刊：
影响因子：
82.9
通讯作者：
Kheradmand, Farrah
中科院分区：
文献类型：
--
作者：
Lee, Seung-Hyo;Goswami, Sangeeta;Kheradmand, Farrah
慢性阻塞性肺疾病和肺气肿是常见的破坏性炎症性疾病，是世界范围内的主要死亡原因。在这里，我们表明，肺气肿是一种自身免疫性疾病的特点是存在抗弹性蛋白抗体和辅助性T细胞1型（T（H）1）的反应，这与肺气肿的严重程度。这些发现将肺气肿与针对特定肺抗原的适应性免疫联系起来，并表明其他富含弹性蛋白的组织（如吸烟者的动脉和皮肤）可能存在自身免疫病理学。
Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.