Over the Counter Availability of Antituberculosis Drugs in Tbilisi, Georgia in the Setting of a High Prevalence of MDR-TB
Over the Counter Availability of Antituberculosis Drugs in Tbilisi, Georgia in the Setting of a High Prevalence of MDR-TB
复制标题
耐多药结核病高发情况下格鲁吉亚第比利斯抗结核药物的非处方药供应情况
DOI：
10.1155/2009/513609
复制
发表时间：
2009
影响因子：
--
通讯作者：
Blumberg,HenryM
中科院分区：
文献类型：
--
作者：
Kobaidze,Ketevan;Salakaia,Archil;Blumberg,HenryM
格鲁吉亚是一个拥有450万人口的国家，结核病(TB)的发病率很高，包括耐药病例。容易获得和不适当使用抗结核药物是进一步发展多药耐药(MDR)结核病的危险因素。我们开展了一项调查，以评估第比利斯药店非处方药抗结核药物的可用性。在2006年2月期间，随机选择了15家药店，并采访了每家药店的药剂师。我们发现，这些药店库存的所有抗结核病药物都是免费提供和出售的。所有15家药店都销售异烟肼、利福平和链霉素；15家药店中有13家(87%)也销售吡津酰胺、乙胺丁醇。二线抗结核药物如阿米卡星和卡那霉素(注射用药)和较老的氟喹诺酮类药物(氧氟沙星和环丙沙星)在13家药店出售，而新一代氟喹诺酮类药物较少(3家出售利沃沙星，没有一家出售莫西沙星)。鉴于包括耐多药结核病在内的结核病在格鲁吉亚的高流行率，抗结核药物的易获得性和可获得性是一个非常令人关切的问题。滥用这些抗结核药物的可能性可能会导致进一步的耐药性发展。这些药物只能通过处方获得，以减少扩大耐药性的机会。
Georgia, a country of 4.5 million people, has a high incidence of tuberculosis (TB) including drug resistant cases. Easy access and inappropriate use of anti‐TB drugs are risk factors for further development of multidrug resistant (MDR)‐TB. We carried out an investigation to assess the availability of over the counter anti‐TB agents in pharmacies in Tbilisi. During February 2006, 15 pharmacies were randomly selected and the pharmacist at each store was interviewed. We found that all anti‐TB medications stocked by these pharmacies were available and sold without a prescription. All 15 pharmacies sold isoniazid, rifampicin, and streptomycin; 13 (87%) of 15 pharmacies also sold pyrazinamide, ethambutol. Second line anti‐TB drugs such as amikacin and kanamycin (injectable agents) and older fluoroquinolones (ofloxacin and ciprofloxacin) were available at 13 pharmacies while newer generation fluoroquinolones were less available(3 sold leovofloxacin, none sold moxifloxacin). The ease access and availability of anti‐TB agents is of a great concern given the high prevalence of TB including MDR‐TB in Georgia. The potential for misuse of these anti‐TB drugs can lead to the development of further drug resistance. These drugs should only be available by prescription in order to reduce the chance of amplifying drug resistance.