extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
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DOI：
10.1016/0092-8674(93)90731-5
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发表时间：
1993-09
期刊：
影响因子：
64.5
通讯作者：
C. Rauskolb;M. Peifer;E. Wieschaus
中科院分区：
文献类型：
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作者：
C. Rauskolb;M. Peifer;E. Wieschaus
果蝇基因exfradenticle（exd）的突变通过改变同源异型选择基因活性的形态结果而引起同源异型转化。我们已经克隆和测序exd：它编码一个同源结构域蛋白与广泛的身份（71%）的人原癌蛋白Pbxl。exd在胚胎发生期间当双足和双胸复合体的选择者同源结构域蛋白建立节段性时表达。母体表达的exd是一致的，可以抑制缺乏合子exd的胚胎的节段转化。虽然合子exd表达最初也是均匀的，但后来的表达受到同源异型选择基因的调节。这些研究支持这样的观点，即exd作为DNA结合转录因子与选择器同源结构域蛋白一起起作用，从而改变它们对下游靶基因的调节。
Mutations in the Drosophila gene exfradenticle(exd) cause homeotic transformations by altering the morphological consequences of homeotic selector gene activity. We have cloned and sequenced exd: it encodes a homeodomain protein with extensive identity (71%) to the human proto-oncoprotein Pbxl. exd is expressed during embryogenesis when the selector homeodomain proteins of the Antennapedia and bithorax complexes establish segmental identity. Maternally expressed exd is uniform and can suppress the segmental transformations of embryos lacking xygotic exd. While zygotic exd expression is also at first uniform, later expression is modulated by the homeotic selector genes. These studies support the view that exd acts with the selector homeodomain proteins as a DNA-binding transcription factor, thereby altering their regulation of downstream target genes.