The Health-Related Quality of Life of Chinese Patients on Hemodialysis and Peritoneal Dialysis
The Health-Related Quality of Life of Chinese Patients on Hemodialysis and Peritoneal Dialysis
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DOI：
10.1007/s40271-017-0256-6
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发表时间：
2017-12-01
影响因子：
3.6
通讯作者：
Lam, Cindy Lo Kuen
中科院分区：
文献类型：
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作者：
Chen, Julie Yun;Wan, Eric Yuk Fai;Lam, Cindy Lo Kuen
Aims我们的目的是比较终末期肾病（ESRD）患者和香港普通人群的健康相关生活质量（HRQOL），以确定透析模式和其他因素如何与HRQOL.Methods我们进行了一项横断面研究，涉及2014-2015年招募的253名血液透析（HD）患者和103名腹膜透析（PD）患者。使用肾脏疾病和生活质量-36（KDQOL-36）子量表评分和简明6维健康量表（SF-6D）健康偏好评分评估其HRQOL。采用单因素方差分析分析PD患者、HD患者和精确年龄和性别匹配的一般人群之间平均KDQOL-36和SF-6D评分的差异。多元线性回归进行评估与KDQOL-36和SF-6D scores.Results透析的ESRD患者的身体HRQOL差于年龄和性别匹配的一般人群（38.4比49.6），但精神HRQOL相似（50.7比52.0）。调整所有基线特征后，男性受试者的身体健康总评（PCS）、SF-6D和症状评分较高。较高的教育水平（中等或高等教育）与较高的心理健康总评（MCS）、SF-6D、症状和效应评分相关。女性，年轻，已婚，受教育程度低，有心血管疾病（CVD）史，并没有达到目标血红蛋白和白蛋白水平的患者与较差的HRQOL outcomes.Conclusions相关的是一个更大的负面影响终末期肾病的日常生活比PD，这可能是一个考虑因素时，决定的透析方式为一线肾脏替代治疗。为了改善维持性透析患者的HRQOL，应更多关注具有人口统计学风险因素的患者，预防CVD，并满足临床透析结局目标，如血红蛋白和白蛋白水平。
Aims Our aim was to compare health-related quality of life (HRQOL) between end-stage renal disease (ESRD) patients and the Hong Kong general population to identify how the mode of dialysis and other factors were associated with HRQOL.Methods We conducted a cross-sectional study involving 253 hemodialysis (HD) patients and 103 peritoneal dialysis (PD) patients recruited in 2014-2015. Their HRQOL was evaluated using Kidney Disease and Quality of Life-36 (KDQOL-36) sub-scale scores and the Short Form-6 Dimensions (SF-6D) health preference score. One-way analysis of variance was used to analyze the difference in mean KDQOL-36 and SF-6D scores among PD patients, HD patients, and an exact age- and sex-matched general population. Multiple linear regressions were conducted to evaluate factors associated with the KDQOL-36 and SF-6D scores.Results The physical HRQOL of ESRD patients on dialysis was worse than that of the age- and sex-matched general population (38.4 vs. 49.6), but mental HRQOL was similar (50.7 vs. 52.0). After adjusting for all baseline characteristics, male subjects was associated with higher physical component summary (PCS), SF-6D, and symptom scores. A higher level of education (secondary or tertiary) was associated with higher mental component summary (MCS), SF-6D, symptom, and effects scores. Patients who were female, younger, married, and less educated and had a history of cardiovascular disease (CVD) and did not achieve target hemoglobin and albumin levels were associated with poorer HRQOL outcomes.Conclusions HD was associated with a greater negative impact of ESRD on daily lives than was PD, which may be a consideration when deciding on the dialysis modality for first-line renal replacement therapy. To improve HRQOL among patients on maintenance dialysis, more attention should be paid to those with demographic risk factors, preventing CVD, and meeting clinical dialysis outcome targets such as hemoglobin and albumin levels.