Elevated levels of Factor XI are associated with cardiovascular disease in women
Elevated levels of Factor XI are associated with cardiovascular disease in women
复制标题
DOI：
10.1016/s0049-3848(02)00190-1
复制
发表时间：
2002-07-15
影响因子：
7.5
通讯作者：
Billett, HH
中科院分区：
文献类型：
--
作者：
Berliner, JI;Rybicki, AC;Billett, HH
冠状动脉疾病（CAD）仍然是美国女性最常见的死亡原因。尽管凝血因子水平升高与CAD相关，但这些研究很少在女性中进行。因子XI水平升高以前与静脉血栓形成有关，但对其对动脉血栓形成的影响知之甚少。我们选择了冠状动脉正常或有严重CAD证据的女性进行心导管检查，并比较了同型半胱氨酸、抗心磷脂IgG/IgM抗体、纤维蛋白原、血小板计数、因子VII、因子VIII和因子XI的水平。患有严重CAD的女性的因子XI水平显著高于没有CAD的女性（128%对82%，p < 0.04）。年龄、糖尿病、高血压、总胆固醇（TC）、当前吸烟或BMI的统计学校正对CAD状态和因子XI之间的独立相关性没有影响。总胆固醇水平>6.18 mmol/l（>239 mg/dl）的女性中因子XI高于正常胆固醇血症的女性，并且在年龄的上三分位数中也较高，但即使调整这些因素，这种关联仍然显着。这项初步研究表明，因子XI可能是动脉和静脉血栓形成的一个重要参数。(C)2002爱思唯尔科技有限公司版权所有。
Coronary artery disease (CAD) continues to be the most frequent cause of death among women in the United States. Although elevated levels of clotting factors have been associated with CAD, few of these studies have been performed in women. Elevated levels of Factor XI have previously been associated with venous thrombosis, but little is known about its effect on arterial thrombosis. We selected women referred for cardiac catheterization who were found to have either normal coronaries or evidence of severe CAD and compared levels of homocysteine, anticardiolipin IgG/IgM antibodies, fibrinogen, platelet count, Factor VII, Factor VIII and Factor XI. Women with severe CAD had significantly higher levels of Factor XI than those without CAD (128% vs. 82%, p < 0.04). Statistical adjustment for age, diabetes, hypertension, total cholesterol (TC), current smoking, or BMI had no effect on the independent association between CAD status and Factor XI. Factor XI was higher in women with total cholesterol levels >6.18 mmol/l(>239 mg/dl) compared with normocholesteremic women and was also higher in the upper tertile of age, but even when adjusted for these, the association remained significant. This initial study suggests that Factor XI may be an important parameter in arterial as well as venous thrombosis. (C) 2002 Elsevier Science Ltd. All rights reserved.