Core body temperature and circadian rhythm of hot flashes in menopausal women.
Core body temperature and circadian rhythm of hot flashes in menopausal women.
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DOI：
10.1210/jcem.80.8.7629229
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发表时间：
1995-08
期刊：
影响因子：
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通讯作者：
R. Freedman;D. Norton;S. Woodward;G. Cornelissen
中科院分区：
文献类型：
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作者：
R. Freedman;D. Norton;S. Woodward;G. Cornelissen
绝经后潮热的特征是出汗和外周血管舒张，并且在热负荷增加时更频繁地发生。核心体温 (TC) 的昼夜节律是众所周知的，表明当核心体温最高时潮热最频繁。这个假设之前没有被测试过。从广告中招募了十名有症状的绝经后妇女和六名无症状的绝经后妇女并进行了筛查。每个人都接受 24 小时胸骨皮肤电导水平动态监测，以检测潮热、环境温度、皮肤温度和 TC。最后一次测量是使用摄入的无线电遥测药丸记录的。余弦分析表明潮热具有昼夜节律（P < 0.02），峰值出现在 1825 小时左右。 0000-0400 小时以及 1500 和 2200 小时有症状女性的 TC 值低于无症状女性 (P < .05)。大多数潮热发生前都会出现 TC 升高。因此，TC 升高可能是更年期潮热的触发因素之一。
Postmenopausal hot flashes are characterized by sweating and peripheral vasodilation and occur more frequently during increased heat loads. The circadian rhythm of core body temperature (TC) is well known and suggests that hot flashes will be most frequent when core temperature is highest. This hypothesis has not been tested previously. Ten symptomatic and six asymptomatic postmenopausal women were recruited from advertisements and screened. Each received 24-h ambulatory monitoring of sternal skin conductance levels to detect hot flashes, ambient temperature, skin temperature, and TC. The last measure was recorded using an ingested radiotelemetry pill. Cosinor analysis demonstrated a circadian rhythm (P < 0.02) of hot flashes with a peak at about 1825 h. TC values of the symptomatic women were lower than those of the asymptomatic women (P < .05) from 0000-0400 h and at 1500 and 2200 h. The majority of hot flashes were preceded by elevations in TC. Thus, elevated TC may serve as one trigger of menopausal hot flashes.