Active site directed inhibitors of replication-specific bacterial DNA polymerases.
Active site directed inhibitors of replication-specific bacterial DNA polymerases.
复制标题
复制特异性细菌 DNA 聚合酶的活性位点定向抑制剂。
DOI：
10.1016/j.bmcl.2004.11.016
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Butler,MichelleM
中科院分区：
文献类型：
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作者：
Wright,GeorgeE;Brown,NealC;Xu,Wei-Chu;Long,Zheng-Yu;Zhi,Chengxin;Gambino,JosephJ;Barnes,MarjorieH;Butler,MichelleM
7-取代- n2 -（3,4-二氯苯）鸟嘌呤可有效抑制革兰氏阳性细菌的DNA聚合酶IIIC和IIIE。某些衍生物也是革兰氏菌DNA聚合酶IIIE的竞争性抑制剂。
7-Substituted-N2-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram+ bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram− bacteria.