An innovative, sensorless, pulsatile, continuous-flow total artificial heart: device design and initial in vitro study.
An innovative, sensorless, pulsatile, continuous-flow total artificial heart: device design and initial in vitro study.
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DOI：
10.1016/j.healun.2009.05.034
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Golding LA
中科院分区：
文献类型：
--
作者：
Fukamachi K;Horvath DJ;Massiello AL;Fumoto H;Horai T;Rao S;Golding LA
我们正在开发一种非常小的、创新的、连续流动的全人工心脏（CFTAH），它可以在没有传感器的情况下被动地自平衡左右泵流量和心房压力。本报告详细介绍了CFTAH设计概念和我们的初始体外数据。使用模拟循环回路评价CFTAH的系统性能，以确定稳态血流条件下达到最大绝对心房压差10 mm Hg的设计目标的全身和肺血管阻力（SVR和PVR）范围。然后将泵速调节为2，600 ± 900 rpm，以诱导流量和动脉压脉动，从而评价速度脉动对系统性能的影响。还评价了自动控制模式。仅使用被动自我调节，泵流量平衡，在远超过正常水平的SVR（750- 2，750 dyne·sec·cm-5）和PVR（135-600 dyne·sec·cm-5）值范围内，绝对心房压差保持在10 mm Hg以下。诱导速度脉动的幅度影响相对左/右性能，允许额外的主动控制以改善平衡的流量和压力。自动控制模式根据SVR和CFTAH流量的无传感器计算调整泵速以实现目标泵流量。CFTAH的初始体外试验采用了单台无阀连续流泵，证明了其流量和心房压力的被动自我调节以及新的自动控制模式。
We are developing a very small, innovative, continuous-flow total artificial heart (CFTAH) that passively self-balances left and right pump flows and atrial pressures without sensors. This report details the CFTAH design concept and our initial in vitro data. System performance of the CFTAH was evaluated using a mock circulatory loop to determine the range of systemic and pulmonary vascular resistances (SVR and PVR) over which the design goal of a maximum absolute atrial pressure difference of 10 mm Hg is achieved for a steady-state flow condition. Pump speed was then modulated at 2,600 ± 900 rpm to induce flow and arterial pressure pulsation to evaluate the effects of speed pulsations on the system performance. An automatic control mode was also evaluated. Using only passive self-regulation, pump flows were balanced and absolute atrial pressure differences were maintained below 10 mm Hg over a range of SVR (750-2,750 dyne·sec·cm-5) and PVR (135-600 dyne·sec·cm-5) values far exceeding normal levels. The magnitude of induced speed pulsatility affected relative left/right performance, allowing for an additional active control to improve balanced flow and pressure. The automatic control mode adjusted pump speed to achieve targeted pump flows based on sensorless calculations of SVR and CFTAH flow. The initial in vitro testing of the CFTAH with a single, valveless, continuous-flow pump demonstrated its passive self-regulation of flows and atrial pressures and a new automatic control mode.
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影响因子：
4.6
作者：
Fukamachi, K;McCarthy, PM;Young, JB
通讯作者：
Young, JB
影响因子：
24
作者：
Matthews, Jennifer Cowger;Koelling, Todd M.;Aaronson, Keith D.
通讯作者：
Aaronson, Keith D.
影响因子：
4.2
作者：
Fukamachi, K;Harasaki, H;Kiraly, RJ
通讯作者：
Kiraly, RJ
DOI：
10.1097/00002480-199207000-00083
发表时间：
1992-07-01
期刊：
ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子：
--
作者：
Fukamachi, K;Irie, H;Kiraly, R J
通讯作者：
Kiraly, R J
影响因子：
8.9
作者：
Dang, NC;Topkara, VK;Naka, Y
通讯作者：
Naka, Y