The Impact of In Utero Exposure to Diabetes on Childhood Body Mass Index Growth Trajectories: The EPOCH Study
The Impact of In Utero Exposure to Diabetes on Childhood Body Mass Index Growth Trajectories: The EPOCH Study
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DOI：
10.1016/j.jpeds.2010.12.007
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发表时间：
2011-06-01
影响因子：
5.1
通讯作者：
Dabelea, Dana
中科院分区：
文献类型：
--
作者：
Crume, Tessa L.;Ogden, Lorraine;Dabelea, Dana
目的探讨在不同的青年队列中，子宫内暴露于母体糖尿病与出生至13岁的体重指数（BMI）增长轨迹之间的关系。研究设计建立了混合线性效应模型，以评估95名在子宫内接触糖尿病的受试者和409名未接触糖尿病的受试者从出生到13岁的BMI和BMI增长速度的差异。结果暴露者和未暴露者从出生到26个月的总体BMI增长轨迹（经性别和种族/民族调整）无显著差异（P = .48）。然而，从27个月大到13岁的总体生长轨迹因暴露状况而异（P = 0.008），并根据性别和种族/民族进行了调整。差异主要是由于10至13岁暴露青少年的BMI增长速度明显较高，与未暴露青少年的3.51 kg/m(2)相比，增加了4.56 kg/m(2) （P = 0.005）。人口统计学变量、社会经济因素和母亲孕前BMI的控制没有改变观察到的关联。结论母体在子宫内暴露于糖尿病会加速儿童期晚期BMI的增长，从而增加长期肥胖的风险。[J] .中华儿科杂志，2011;58:941-6。
Objective To examine associations between exposure to maternal diabetes in utero and body mass index (BMI) growth trajectories from birth through 13 years of age among a diverse cohort of youth.Study design Mixed linear effects models were constructed to assess differences in BMI and BMI growth velocity from birth through 13 years of age for 95 subjects exposed to diabetes in utero and 409 unexposed subjects enrolled in a retrospective cohort study.Results The overall BMI growth trajectory (adjusted for sex and race/ethnicity) was not significantly different for exposed and unexposed subjects from birth through 26 months of age (P = .48). However, the overall growth trajectory from 27 months of age through 13 years differed by exposure status (P = .008), adjusted for sex and race/ethnicity. The difference was primarily due to a significantly higher BMI growth velocity among exposed youth between 10 and 13 years, increasing by 4.56 kg/m(2) compared with 3.51 kg/m(2) in the unexposed (P = .005). Control for demographic variables, socioeconomic factors, and maternal prepregnancy BMI did not alter the observed associations.Conclusions Exposure to maternal diabetes in utero accelerates BMI growth in late childhood, thus increasing long-term obesity risk. (J Pediatr 2011;158:941-6).