Electrodeposition of amine-terminatedpoly(ethylene glycol) to titanium surface
Electrodeposition of amine-terminatedpoly(ethylene glycol) to titanium surface
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DOI：
10.1016/j.msec.2006.03.007
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发表时间：
2007-03
期刊：
影响因子：
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通讯作者：
Yuta Tanaka;H. Doi;Y. Iwasaki;S. Hiromoto;T. Yoneyama;K. Asami;H. Imai;T. Hanawa
中科院分区：
文献类型：
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作者：
Yuta Tanaka;H. Doi;Y. Iwasaki;S. Hiromoto;T. Yoneyama;K. Asami;H. Imai;T. Hanawa
将聚乙二醇（PEG）固定在固体表面有助于使表面功能化，例如防止蛋白质的吸附。目前还没有成功的一段固定PEG到贱金属的技术。在本研究中，采用电沉积的方法将两个末端或一个末端被胺基修饰的聚乙二醇固定在钛表面。将聚乙二醇溶解在NaCl溶液中，在−5 V、310 K下电沉积300 min。利用椭偏仪评价了沉积的PEG层厚度，并利用x射线光电子能谱分析了电沉积后PEG与钛表面的键合方式。结果表明：用胺终止聚乙二醇时，通过电沉积和浸泡两种方式均能吸附一定量的聚乙二醇。然而，端部胺存在于钛的表面，并通过电沉积与氧化钛结合成N-HO，而胺则随机存在于分子中，并通过浸泡与氧化钛形成离子键。聚乙二醇电沉积对白蛋白吸附有明显的抑制作用。这一过程对具有导电性和复杂形态的材料是有用的。
The immobilization of poly(ethylene glycol), PEG, to a solid surface is useful to functionalize the surface, e.g., to prevent the adsorption of proteins. No successful one-stage technique for the immobilization of PEG to base metals has ever been developed. In this study, PEG in which both terminals or one terminal had been modified with amine bases was immobilized onto a titanium surface using electrodeposition. PEG was dissolved in a NaCl solution, and electrodeposition was carried out at 310 K with −5 V for 300 min. The thickness of the deposited PEG layer was evaluated using ellipsometry, and the bonding manner of PEG to the titanium surface was characterized using X-ray photoelectron spectroscopy after electrodeposition. The results indicated that a certain amount of PEG was adsorbed on titanium through both electrodeposition and immersion when PEG was terminated by amine. However, terminated amines existed at the surface of titanium and were combined with titanium oxide as N–HO by electrodeposition, while amines randomly existed in the molecule and showed an ionic bond with titanium oxide by immersion. The electrodeposition of PEG was effective for the inhibition of albumin adsorption. This process is useful for materials that have electroconductivity and a complex morphology.