Direct measurement of lung motion using hyperpolarized helium-3 MR tagging
Direct measurement of lung motion using hyperpolarized helium-3 MR tagging
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DOI：
10.1016/j.ijrobp.2007.02.011
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发表时间：
2007-07-01
影响因子：
7
通讯作者：
Sheng, Ke
中科院分区：
文献类型：
--
作者：
Cai, Jing;Miller, G. Wilson;Sheng, Ke
目的：为了测量肺运动之间的吸气末和呼气末使用超极化氦-3（HP He-3）磁共振（MR）taggingtechnique.Methods and Materials：三名健康志愿者进行了MR标记研究后吸入1 L HP 3 He气体稀释氮气。结果：Hp 3 He在吸气末和呼气末的MR图像中标记线网格清晰，呼气末标记线网格清晰，在吸气末和呼气末的MR图像中标记线网格清晰，在呼气末的MR图像中标记线网格清晰，在吸气末和呼气末的MR图像中标记线网格清晰。位移矢量图清楚地显示了呼气过程中发生的局部肺运动和变形。两个相邻肺叶之间的运动模式的不连续性和差异很容易resolved.Conclusions：超极化氦-3 MR标记技术可以用于直接在体内测量呼吸肺运动的区域基础上。该技术可以提供新的见解的区域肺生物力学，从而提供有价值的信息，肺的变形配准。(c)2007年爱思唯尔公司
Purpose: To measure lung motion between end-inhalation and end-exhalation using a hyperpolarized helium-3 (HP He-3 magnetic resonance (MR) tagging technique.Methods and Materials: Three healthy volunteers underwent MR tagging studies after inhalation of 1 L Hp 3He gas diluted with nitrogen. Multiple-slice two-dimensional and volumetric three-dimensional MR tagged images of the lungs were obtained at end-inhalation and end-exhalation, and displacement vector maps were computed.Results: The grids of tag lines in the Hp 3He MR images were well defined at end-inhalation and remained evident at end-exhalation. Displacement vector maps clearly demonstrated the regional lung motion and deformation that occurred during exhalation. Discontinuity and differences in motion pattern between two adjacent lung lobes were readily resolved.Conclusions: Hyperpolarized helium-3 MR tagging technique can be used for direct in vivo measurement of respiratory lung motion on a regional basis. This technique may lend new insights into the regional pulmonary biomechanics and thus provide valuable information for the deformable registration of lung. (c) 2007 Elsevier Inc.