AGING AND THE PHYSIOLOGY OF SPATIAL MEMORY
AGING AND THE PHYSIOLOGY OF SPATIAL MEMORY
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DOI：
10.1016/s0197-4580(88)80114-3
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发表时间：
1988-09-01
影响因子：
4.2
通讯作者：
BARNES, CA
中科院分区：
文献类型：
--
作者：
BARNES, CA
啮齿动物和人类的空间记忆与年龄相关的变化的证据，沿着的数据表明，海马结构是必要的正常性能的空间任务，在这两个物种。对大鼠海马结构的电生理学特征的研究表明，随着年龄的增长，海马结构发生的变化是有选择性的，但至少有两种主要类型的改变导致了这些动物的空间认知障碍。这些包括维持突触增强的能力的缺陷和单个海马神经元的信息处理能力的准确性降低。
Evidence for age-related changes in spatial memory in rodents and humans is presented, along with data that suggest that the hippocampal formation is necessary for normal performance on spatial tasks in both species. An examination of the electrophysiological characteristics of this structure in rats suggests that the changes that occur with age in the hippocampus are selective, but that at least two primary types of alterations contribute to the spatial cognitive impairment seen in these animals. These include a deficit in the ability to maintain synaptic enhancement and a reduction in the accuracy of information processing ability of single hippocampal neurons.