Ontogeny of the cytoplasmic androgen receptor in the rat ventral prostate gland.
Ontogeny of the cytoplasmic androgen receptor in the rat ventral prostate gland.
复制标题
大鼠腹侧前列腺细胞质雄激素受体的个体发育。
DOI：
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发表时间：
1980
影响因子：
3.6
通讯作者：
Philip H. Petra
中科院分区：
文献类型：
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作者：
Jacob Rajfer;P. Namkung;Philip H. Petra
在动物性成熟之前、之时和之后的不同时间段测量雄性大鼠腹侧前列腺的胞质雄激素受体的浓度。前列腺二氢睾酮 (DHT) 受体从出生后早期（第 16 天）的 29 飞摩尔 (fm)/mg 胞质蛋白逐渐增加到大鼠性成熟时（第 50 天）的峰值 87 fm/mg 蛋白。此后，受体浓度在第 70 天时急剧下降至 19 fm/mg 蛋白质的水平。这些结果表明，在这些时间段内观察到的前列腺DEIT受体的水平可能对大鼠腹侧前列腺的印记机制很重要，已知这种印记发生在大鼠第35天和第65天之间的某个时间。
The concentration of the cytosolic androgen receptor of the ventral prostate gland of the male rat was measured at various time periods prior to, at the time of, and following the sexual maturation of the animal. The prostatic dihydrotestosterone (DHT) receptor gradually increased from 29 femtomoles (fm)/mg cytosol protein during the early postnatal period (Day 16 of age) to a peak of 87 fm/mg protein around the time when the rat attains sexual maturity (Day 50 of age). Following this, the receptor concentration declined precipitously to a level of 19 fm/mg protein at Day 70 of age. These results suggest that the level of the prostatic DEIT receptor observed during these time periods may be important in the imprinting mechanism of the rat ventral prostate gland that is known to occur in the rat sometime between Day 35 and Day 65 of age.