A new approach to prepare well-dispersed CaF(2) nanoparticles by spray drying technique.
A new approach to prepare well-dispersed CaF(2) nanoparticles by spray drying technique.
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喷雾干燥制备分散良好的CaF(2)纳米粒子的新方法
DOI：
10.1002/jbm.b.31800
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Mitchell,JamesW
中科院分区：
文献类型：
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作者：
Sun,Limin;Chow,LaurenceC;Bonevich,JohnE;Wang,Tongxin;Mitchell,JamesW
在此之前，纳米级的氟化钙(CaF2)颗粒是通过喷雾干燥的方法同时将Ca(OH)2和NH4F溶液加入双液喷嘴来制备的。本研究的目的是通过共形成可溶盐氯化钠(NaC L)来制备分散更好的纳米CaF2粒子。在NH4F溶液中加入不同浓度的氯化钠，得到CaF2/氯化钠摩尔比分别为4/1、4/4和4/16的(CaF2+氯化钠)复合材料，并以纯纳米CaF2为对照。粉末X-射线衍射分析表明，产物中含有结晶的CaF2和氯化钠。扫描电子显微镜分析表明，CaF2/氯化钠复合粒子和纯CaF2粒子的尺寸都在(50-800)nm左右，主要由50 nm的初级CaF2粒子组成。BET表面积测量显示，所有样品的初级颗粒尺寸相似。动态光散射测量表明，洗涤后的(CaF2+NaCl2)粒子比纯CaF2粒子小得多，这是因为氯化钠的溶解“释放”了大部分初级CaF2粒子，导致了粒子的分散程度更高。分散良好的纳米CaF2有望成为比NaF更有效的防龋剂，因为它可以更持久地提高口腔液体中的氟化物浓度。《生物材料资源》第B部分：APPL Biomater，2011。
Previously, nano‐sized calcium fluoride (CaF2) particles were prepared using a spray drying method by simultaneously feeding Ca(OH)2and NH4F solutions to a two‐liquid nozzle. The aim of the present study was to prepare better‐dispersed nano‐CaF2particles by co‐forming a soluble salt, sodium chloride (NaCl). NaCl of various concentrations were added to the NH4F solution, leading to formation of (CaF2+NaCl) composites with CaF2/NaCl molar ratios of 4/1, 4/4, and 4/16. Pure nano‐CaF2was also prepared as the control. Powder X‐ray diffraction analysis showed that the products contained crystalline CaF2and NaCl. Scanning electron microscopy examinations showed that both the CaF2/NaCl composite and pure CaF2particles were about (50–800) nm in size and consisted of primary CaF2particles of < 50 nm in size. BET surface area measurements showed similar primary particle sizes for all samples. Dynamic light scattering measurements showed that the washed (CaF2+NaCl) particles were much smaller than the pure CaF2as the dissolution of NaCl “freed” most of the primary CaF2particles, leading to a greater degree of particle dispersion. The well‐dispersed nano‐CaF2may be expected to be a more effective anticaries agent than NaF by providing longer lasting elevations of fluoride concentrations in oral fluids. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.