Reconstruction of calvarial bone defects using poly(amino acid)/hydroxyapatite/calcium sulfate composite
Reconstruction of calvarial bone defects using poly(amino acid)/hydroxyapatite/calcium sulfate composite
复制标题
聚氨基酸/羟基磷灰石/硫酸钙复合材料重建颅骨骨缺损
DOI：
10.1080/09205063.2018.1554833
复制
发表时间：
2019-01-22
影响因子：
3.6
通讯作者：
Yan, Yonggang
中科院分区：
文献类型：
--
作者：
Fan, Xiaoxia;Peng, Haitao;Yan, Yonggang
摘要本研究的目的是评估聚氨基酸（PAA）和含有PAA、羟基磷灰石（HA）和硫酸钙（CS）的复合材料的热性能和体内界面性能，以确定它们是否适合用于颅骨修复。通过将材料植入家兔肌肉中8周来评价生物相容性。通过将PAA、致密PAA/HA/CS复合材料（c-PAA/HA/CS）和单侧多孔PAA/HA/CS复合材料（p-PAA/HA/CS）植入兔颅骨缺损中来评估颅骨修复。结果表明，PAA/HA/CS复合材料具有良好的耐热性、生物相容性和骨传导性。引导骨再生和颅骨修复，颅骨组织与种植体之间的结合良好。p-PAA/HA/CS复合材料在稳定性和植入物与宿主骨组织之间的骨结合方面表现最好。因此，目前的工作提供了新的信息，具有宏观结构的骨传导PAA/HA/CS复合材料在颅骨修复的潜在用途。
Abstract The aim of this study was to evaluate the thermal properties and in vivo interface performance of poly(amino acid) (PAA) and a composite containing PAA, hydroxyapatite (HA), and calcium sulfate (CS), with respect to their suitability for skull repair. Biocompatibility was evaluated by implantation of materials into muscles of rabbits for eight weeks. Skull repair was assessed by implanting PAA, the compact PAA/HA/CS composite (c-PAA/HA/CS), and a one-side-porous PAA/HA/CS composite (p-PAA/HA/CS) into rabbit calvarial defects. The results showed that the PAA/HA/CS composite possessed good heat resistance and possessed excellent biocompatibility and osteoconductivity. Guided bone regeneration and calvarial repair were observed, with excellent integration between calvarial tissue and implant. The p-PAA/HA/CS composite performed best in terms of stability and bone bonding between implant and host bone tissue. Thus, the present work provides new information for the potential use of osteoconductive PAA/HA/CS composites with a macrostructure in calvarial bone repair.