Metallothionein content increased in the liver of mice exposed to magnetic fields
Metallothionein content increased in the liver of mice exposed to magnetic fields
复制标题
暴露于磁场的小鼠肝脏中金属硫蛋白含量增加
DOI：
10.1007/s002040050280
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发表时间：
1996
影响因子：
6.1
通讯作者：
H. Shimizu
中科院分区：
文献类型：
--
作者：
M. Satoh;Y. Tsuji;Y. Watanabe;H. Okonogi;Y. Suzuki;M. Nakagawa;H. Shimizu
摘要 虽然最近的研究表明，不同的应激可以诱导动物组织中金属硫蛋白(MT)的合成，但利用静磁场诱导MT合成的报道尚未见报道。我们测定了SMF染毒小鼠肝脏、肾脏和脑组织中MT的水平，并评价了SMF染毒对四氯化碳(CCl4)诱导的小鼠肝脏MT的影响。经4.7 -T染毒6、24、48 h后，小鼠肝脏MT含量显著升高，而肾脏和脑组织MT含量与对照组相比无明显变化。注射CCl_4和SMF联合作用后，小鼠肝脏MT含量明显升高，高于单独用药时的水平。这些结果表明，暴露于强SMF可诱导小鼠肝脏MT合成，并增强CCl4诱导的小鼠肝脏MT合成。
Abstract Although recent studies have shown that various stress can induce metallothionein (MT) synthesis in animal tissues, the induction of MT synthesis by exposure to static magnetic fields (SMF) has not been reported. We measured MT levels in the liver, kidney and brain of mice exposed to SMF and also evaluated the effect of SMF exposure on the induction of hepatic MT by treatment with carbon tetrachloride (CCl4). The MT content in the liver was significantly increased by exposure to 4.7 T of SMF for 6, 24, or 48 h, whereas that in the kidney or brain was not changed compared to the control. The combination of CCl4 injection and SMF exposure induced elevation of the hepatic MT content exceeding that induced by either treatment alone. These results indicate that exposure to the strong SMF induces MT synthesis in the liver in mice and enhances the hepatic MT synthesis induced by CCl4 administration.
影响因子：
3.8
作者：
BAUMAN, JW;LIU, J;KLAASSEN, CD
通讯作者：
KLAASSEN, CD