Relative risk of prostate cancer for men with affected relatives: Systematic review and meta-analysis
Relative risk of prostate cancer for men with affected relatives: Systematic review and meta-analysis
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DOI：
10.1002/ijc.11466
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发表时间：
2003-12-10
影响因子：
6.4
通讯作者：
Engstrom, P
中科院分区：
文献类型：
--
作者：
Bruner, DW;Moore, D;Engstrom, P
多项已发表的报告均记录了与前列腺癌家族史相关的前列腺癌风险增加。已证明风险因受影响亲属的关系程度和发病年龄而异。多项研究采用不同的设计，估计了这些关联的相对风险 (RR)。我们研究的目的是识别和总结已发表的关于前列腺癌风险与家族史之间关系的报告，家族史被定义为有父亲、兄弟、任何一级或二级亲属或其他患有前列腺癌的亲属。从 1982 年到 2000 年，Medline 和人工检索确定了 24 项报告 RR 和置信区间 (CI) 并满足纳入标准的研究。基于加权平均模型的汇总 RR 估计如下：任何受影响的家庭成员 RR = 1.93，Cl 1.65-2.26；受影响的一级亲属 RR = 2.22，CI 2.06-2.40；受影响的二级亲属 RR = 1.88，CI 1.54-2.30；父亲患有前列腺癌 RR = 2.12，CI 1.82-2.5 1；和患有前列腺癌的兄弟 RR = 2.87，CI 2.21-3.73）。汇总数据的统计比较表明，受影响的兄弟的 RR 显着高于受影响的父亲 (p < 0.03)。敏感性分析表明，这些结果在总体偏差方面是稳健的。这项荟萃分析证实，前列腺癌的风险与家族病史相关，并提高了这种风险的量化水平。 (C) 2003 Wiley-Liss, Inc.
An increased risk of prostate cancer associated with a family history of prostate cancer has been documented in multiple published reports. Risk has been shown to vary by degree of relationship and age of onset of disease in the affected relative. Several studies, using various designs, have estimated the relative risk (RR) for these associations. The purpose of our study was to identify and summarize published reports on the relationship between risk of prostate cancer and family history, which is defined as having a father, brother, any first- or second-degree relative or other relative affected with prostate cancer. A Medline and manual search from 1982 to 2000 identified 24 studies that reported RR an confidence intervals (CI) and satisfied inclusion criteria. Pooled RR estimates based upon a weighted average model were as follows: any affected family member RR = 1.93, Cl 1.65-2.26; affected first-degree relative RR = 2.22, CI 2.06-2.40; affected second-degree relative RR = 1.88, CI 1.54-2.30; father with prostate cancer RR = 2.12, CI 1.82-2.5 1; and brother with prostate cancer RR = 2.87, CI 2.21-3.73). Statistical comparison of pooled data demonstrated that the RR is significantly higher for affected brother than for affected father (p < 0.03). A sensitivity analysis demonstrated that these results are robust with respect to population bias. This meta-analysis confirms that risk of prostate cancer is associated with family history of disease and improves the quantification of this risk. (C) 2003 Wiley-Liss, Inc.