Immunity to poliomyelitis, diphtheria and tetanus in pediatric patients before and after renal or liver transplantation
Immunity to poliomyelitis, diphtheria and tetanus in pediatric patients before and after renal or liver transplantation
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DOI：
10.1016/s0264-410x(99)00064-x
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发表时间：
1999-06-04
期刊：
影响因子：
5.5
通讯作者：
Luraschi, C
中科院分区：
文献类型：
--
作者：
Balloni, A;Assael, BM;Luraschi, C
很少有研究考虑儿童患者在实体器官移植前后接种疫苗的安全性、有效性和适宜性。为了解儿童肝移植前后白喉、破伤风、脊髓灰质炎疫苗接种后的免疫状况，以及肾移植前后儿童脊髓灰质炎的免疫状况，所有患者均接受了完整的白喉、破伤风、脊髓灰质炎初免程序。对J6例肾移植患者、27例慢性透析患者和33例对照组、39例肝移植患者、25例慢性肝功能衰竭患者和36例对照组进行了对三种脊髓灰质炎病毒的免疫力评估。对52例肝移植患者、79例慢性肝功能衰竭患儿和54例健康儿童进行了白喉和破伤风免疫试验。肾移植患者的脊髓灰质炎病毒1型和2型抗体几何平均滴度低于健康对照组，而儿童肝移植患者的保护性与其对照组相似。慢性肝功能衰竭患者白喉、脊髓灰质炎病毒1型和3型抗体几何平均滴度高于对照组，移植后免疫抑制对肾移植患儿初次接种疫苗后的免疫状态有负面影响。而慢性肝功能衰竭儿童的抗体水平高于正常人群。在可能的情况下，建议将高危患者的免疫计划个体化。(C)1999爱思唯尔科学有限公司。保留所有权利。
Few studies have considered the safety, efficacy and appropriateness of vaccinations in pediatric patients before and after solid organ transplantation. The aim of this study was to evaluate the immune status after primary vaccination to diphtheria, tetanus and poliomyelitis in pediatric patients before and after hepatic transplantation and to poliomyelitis in pediatric patients before and after renal transplantation.All the patients had received a complete primary immunization schedule for diphtheria and tetanus and poliomyelitis;. Immunity to the three polioviruses was evaluated in j6 patients with:renal transplant, 27 on chronic dialysis and 33 controls and in 39 patients with hepatic transplant, 25 with chronic hepatic failure and their 36 controls. Immunity to diphtheria and tetanus was evaluated in 52 liver transplant patients, 79 children with chronic hepatic failure and 54 healthy children. Renal transplant patients were less protected and had lower antibody geometric mean titers than healthy controls for polioviruses 1 and 2. Whereas, protection in the children liver transplant patients was similar to that in their controls. Patients with chronic hepatic failure had higher antibody geometric mean titers to diphtheria and polioviruses 1 and 3 than their control group.Immunosuppression after transplantation has a negative influence on the immune status after primary vaccination in children with renal transplant. Whereas children with chronic hepatic failure have higher antibodies than a normal population. When possible, it could be advisable to individualize immunization schedules in patients at high risk. (C) 1999 Elsevier Science Ltd. All rights reserved.