Histone deacetylase HDAC1 expression correlates with the progression and prognosis of lung cancer: A meta-analysis.
Histone deacetylase HDAC1 expression correlates with the progression and prognosis of lung cancer: A meta-analysis.
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DOI：
10.1097/md.0000000000007663
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发表时间：
2017-08
期刊：
影响因子：
1.6
通讯作者：
Jia M
中科院分区：
文献类型：
--
作者：
Cao LL;Song X;Pei L;Liu L;Wang H;Jia M
组蛋白去乙酰化酶1（HDAC 1）是一种重要的表观遗传因子，被认为与某些类型癌症的进展和预后有关。HDAC 1在肺癌中有过表达的报道，但HDAC 1过表达与肺癌临床特征及预后的关系仍存在争议。在这项研究中，我们研究了HDAC 1与肺癌之间的潜在联系。检索Embase、Web of Science、PubMed和其他来源的相关研究。计算合并比值比（OR）或风险比（HR）及其95%置信区间（CI），以评估HDAC 1与肺癌风险的相关性。最终荟萃分析纳入了8项合格研究。HDAC 1 mRNA或蛋白表达与肺癌分化程度密切相关（OR = 2.36，95% CI = 1.14-4.87，P = 0.02）。 HDAC 1蛋白在鳞癌中的表达水平高于腺癌（OR = 1.81，95% CI = 1.13-2.90，P =.01）。 HDAC 1 mRNA或蛋白表达与肺癌患者的总生存率呈负相关（HR = 2.40，95%CI = 1.48-3.88，P = 0.0004）。 在这项荟萃分析中，我们的结果表明HDAC 1可能作为肺癌的一个良好的诊断和预后标志物。
Supplemental Digital Content is available in the text Histone deacetylase 1 (HDAC1) is an important epigenetic factor, and is thought to be associated with the progression and prognosis of some types of cancer. HDAC1 has been reported to be overexpressed in lung cancer, but the correlation between HDAC1 overexpression and the clinical features or prognosis of lung cancer is controversial. In this study, we investigated the potential association between HDAC1 and lung cancer. Embase, Web of Science, PubMed, and other sources were searched for relevant studies. Pooled odds ratios (ORs) or hazard ratios (HRs) with 95% confidence interval (CI) were calculated to evaluate the association of HDAC1 with lung cancer risk. Eight eligible studies were included in the final meta-analysis. We found that HDAC1 mRNA or protein expression was closely associated with the differentiation grade of lung cancer (OR = 2.36, 95% CI = 1.14–4.87, P = .02). In addition, the protein expression level of HDAC1 in squamous cell carcinoma was higher than that in adenocarcinoma (OR = 1.81, 95% CI = 1.13–2.90, P = .01). Finally, HDAC1 mRNA or protein expression was negatively correlated with the overall survival rate of patients with lung cancer (HR = 2.40, 95% CI = 1.48–3.88, P = .0004). In this meta-analysis, our results suggest that HDAC1 may serve as a good diagnostic and prognostic marker for lung cancer.