Regulation of epithelial cell adhesion and repulsion: role of endocytic recycling.
Regulation of epithelial cell adhesion and repulsion: role of endocytic recycling.
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DOI：
10.2152/jmi.55.9
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发表时间：
2008-02
期刊：
影响因子：
--
通讯作者：
N. Nishimura;Takuya Sasaki
中科院分区：
文献类型：
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作者：
N. Nishimura;Takuya Sasaki
在上皮-间充质转化和间充质-上皮转化过程中，细胞粘附和排斥之间的适当平衡对于细胞形态发生至关重要。已知许多配体-受体对包括肝细胞生长因子/分散因子-Met和脑信号蛋白-丛蛋白通过复杂的细胞内信号传导途径来控制这种平衡。细胞与其他细胞和细胞外基质（ECM）的粘附分别由细胞粘附分子（CAM）和ECM受体介导，其通过多种斑块蛋白加强和/或减弱粘附活性与细胞骨架相关。细胞排斥需要下调细胞粘附和细胞骨架动力学的广泛变化。CAM和ECM受体的内吞再循环最近已成为控制细胞粘附和排斥之间平衡的重要机制。与CasL相互作用的分子（MICAL）家族蛋白最初被鉴定为与ECM受体整联蛋白相关的斑块蛋白，并且涉及脑信号蛋白-丛蛋白依赖的排斥性轴突引导。我们最近发现MICAL家族蛋白JRAB/MICAL-L2作为Rab家族小G蛋白Rab 13的效应蛋白发挥作用，调节紧密连接CAM occludin的内吞再循环，并控制上皮细胞的粘附和排斥。
A proper balance between cell adhesion and repulsion is essential for cellular morphogenesis during epithelial-mesenchymal transition and mesenchymal-epithelial transition. A number of ligand-receptor pairs including hepatocyte growth factor/scatter factor-Met and semaphorin-plexin are known to control this balance through the complex intracellular signaling pathways. Cell adhesion to other cells and extracellular matrix (ECM) is mediated by cell adhesion molecules (CAMs) and ECM receptors, respectively, which are associated with cytoskeleton through a variety of plaque proteins strengthening and/or weakening adhesion activities. Cell repulsion requires the downregulation of cell adhesion and the extensive changes in cytoskeletal dynamics. The endocytic recycling of CAMs and ECM receptors has recently emerged as an important mechanism to control the balance between cell adhesion and repulsion. Molecule interacting with CasL (MICAL) family proteins are originally identified as a plaque protein associated with ECM receptors integrins and implicated in semaphorin-plexin dependent repulsive axon guidance. We have recently shown that MICAL family protein JRAB/MICAL-L2 functions as an effector protein for Rab family small G protein Rab13 and regulates the endocytic recycling of tight junctional CAM occludin and controls the adhesion and repulsion of epithelial cells.