An enantiodivergent and formal synthesis of paroxetine enantiomers by asymmetric desymmetrization of 3-(4-fluorophenyl)glutaric anhydride with a chiral SuperQuat oxazolidin-2-one
An enantiodivergent and formal synthesis of paroxetine enantiomers by asymmetric desymmetrization of 3-(4-fluorophenyl)glutaric anhydride with a chiral SuperQuat oxazolidin-2-one
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DOI：
10.1016/j.tetasy.2012.08.001
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发表时间：
2012-08-31
影响因子：
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通讯作者：
Ghosh, Sunil K.
中科院分区：
文献类型：
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作者：
Chaubey, Narendra R.;Ghosh, Sunil K.
研究了3-（4-氟苯基）戊二酸酐9与锂化手性恶唑烷-2-酮8的不对称脱对称反应。不对称产物与>90% de形成，并转化为(+)-和(-)-帕罗西汀的已知中间体。(c) 2012 Elsevier Ltd.版权所有。
The asymmetric desymmetrization of 3-(4-fluorophenyl)glutaric anhydride 9 with lithiated chiral oxazolidin-2-one 8 has been studied. The desymmetrized product was formed with >90% de and converted into known intermediates for both (+)- and (-)-paroxetines. (c) 2012 Elsevier Ltd. All rights reserved.