Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague–Dawley rats
Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague–Dawley rats
复制标题
DOI：
10.1016/j.nbd.2007.07.027
复制
发表时间：
2008-01
影响因子：
6.1
通讯作者：
Shuang Wang;Deng-chang Wu;M. Ding;Qing Li;Zhen-bing Zhuge-;Shihong Zhang;Zhong Chen
中科院分区：
文献类型：
--
作者：
Shuang Wang;Deng-chang Wu;M. Ding;Qing Li;Zhen-bing Zhuge-;Shihong Zhang;Zhong Chen
对点燃灶或梨状皮质进行低频刺激（LFS）可抑制点燃癫痫发生，但对边缘系统以外的脑靶点进行LFS是否具有抗惊厥作用尚不清楚。本研究旨在探讨小脑顶核（FN）LFS对杏仁核点燃癫痫发作的影响。每日点燃刺激（60 Hz，100-300 μA，1 ms脉冲串，1 s）后立即刺激同侧FN，1Hz（15 min，0.1 ms脉冲串，100 μ A），而不是3 Hz，显著抑制点燃获得中的癫痫发作阶段和后放电持续时间。对侧FH的1 Hz或3 Hz刺激均无任何显著影响。有趣的是，延迟交付（后放电停止后立即）的LFS在同侧FN加速点燃收购的速度相比，控制。我们的研究表明，LFS的边缘系统以外的目标，如FN，可能有显着的抗癫痫作用，LFS的效果取决于刺激的频率和时间。
Low-frequency stimulation (LFS) of the kindling focus or the piriform cortex inhibits kindling epileptogenesis, but whether LFS of brain targets outside the limbic system has anticonvulsive actions remain unknown. The current study was designed to investigate the effect of LFS of the cerebellar fastigial nucleus (FN) on seizure progression induced by amygdaloid kindling. Stimulation at 1 Hz (15-min train of 0.1-ms pulses, 100 μA), but not at 3 Hz, in the ipsilateral FN immediately after the daily kindling stimulus (1-s train of 1-ms pulses at 60 Hz and 100–300 μA) significantly inhibited the seizure stage and afterdischarge duration in kindling acquisition. Neither 1 Hz nor 3 Hz stimulation of the contralateral FH had any significant effect. It is interesting that delaying delivery (immediately after the cessation of afterdischarge) of LFS in the ipsilateral FN accelerated the rate of kindling acquisition compared to controls. Our study suggests that LFS of targets outside the limbic system, such as the FN, may have a significant anti-epileptogenic action, and the effects of LFS depend on the frequency and timing of stimulation.