Exposure to Bisphenol A From Drinking Canned Beverages Increases Blood Pressure Randomized Crossover Trial
Exposure to Bisphenol A From Drinking Canned Beverages Increases Blood Pressure Randomized Crossover Trial
复制标题
DOI：
10.1161/hypertensionaha.114.04261
复制
发表时间：
2015-02-01
期刊：
影响因子：
8.3
通讯作者：
Hong, Yun-Chul
中科院分区：
文献类型：
--
作者：
Bae, Sanghyuk;Hong, Yun-Chul
双酚A （BPA）是一种用于塑料瓶和饮料罐内涂层的化学物质，它的暴露几乎无处不在。在之前的研究中，BPA与高血压和心率变异性降低有关。本研究的目的是确定食用罐装饮料所增加的BPA暴露是否真的会影响血压和心率变异性。我们进行了一项随机交叉试验，从当地社区中心招募的年龄为60岁的非机构成年人。总共有60名参与者到研究现场三次，每次给他们提供2个玻璃瓶、2个易拉罐或1个易拉罐和1个玻璃瓶装的相同饮料。饮料的顺序是随机的。然后，我们在饮用每一种饮料2小时后测量尿液中的BPA浓度、血压和心率变异性。采用配对t检验和混合模型比较差异。与饮用玻璃瓶装饮料相比，饮用罐装饮料后尿液BPA浓度增加了1600%。与饮用两杯瓶装饮料相比，饮用两杯罐装饮料后的收缩压经日方差调整后约增加4.5 mm Hg，差异具有统计学意义。两组心率变异性参数差异无统计学意义。目前的研究表明，饮用罐装饮料和随之而来的BPA暴露增加会急剧增加血压。
Bisphenol A (BPA) is a chemical used in plastic bottles and inner coating of beverage cans, and its exposure is almost ubiquitous. BPA has been associated with hypertension and decreased heart rate variability in the previous studies. The aim of the present study was to determine whether increased BPA exposure from consumption of canned beverage actually affects blood pressure and heart rate variability. We conducted a randomized crossover trial with noninstitutionalized adults, who were aged >= 60 years and recruited from a local community center. A total of 60 participants visited the study site 3 times, and they were provided the same beverage in 2 glass bottles, 2 cans, or 1 can and 1 glass bottle at a time. The sequence of the beverage was randomized. We then measured urinary BPA concentration, blood pressure, and heart rate variability 2 hours after the consumption of each beverage. The paired t test and mixed model were used to compare the differences. The urinary BPA concentration increased after consuming canned beverages by >1600% compared with that after consuming glass bottled beverages. Systolic blood pressure adjusted for daily variance increased by approximate to 4.5 mm Hg after consuming 2 canned beverages compared with that after consuming 2 glass bottled beverages, and the difference was statistically significant. The parameters of the heart rate variability did not show statistically significant differences. The present study demonstrated that consuming canned beverage and consequent increase of BPA exposure increase blood pressure acutely.