Recent Advances in Reactive Oxygen Species (ROS)-Responsive Polyfunctional Nanosystems 3.0 for the Treatment of Osteoarthritis.
Recent Advances in Reactive Oxygen Species (ROS)-Responsive Polyfunctional Nanosystems 3.0 for the Treatment of Osteoarthritis.
复制标题
活性氧（ROS）响应性多功能纳米系统3.0治疗骨关节炎的最新进展
DOI：
10.2147/jir.s373898
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发表时间：
2022
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
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作者：
骨关节炎（OA）是一种炎症性和退行性关节疾病，对个人、社会和经济产生严重影响，影响着世界各地数百万老年人。到目前为止，还没有有效的治疗OA的方法;然而，有一些治疗方法可以减缓或阻止其进展。多功能纳米系统具有控制释放、靶向治疗和高载药率等优点，已广泛应用于OA的治疗。以往的机制研究表明，炎症和活性氧是相互关联的，大量的研究表明，活性氧在不同类型的OA的发展中发挥重要作用。在这篇综述文章中，我们总结了第三代ROS敏感的纳米材料，在体内从软骨细胞和破骨细胞中抑制过量的ROS。我们只关注基于聚合物的纳米颗粒（NPs），而不回顾载药或重金属NPs的影响。越来越多的证据表明，多功能纳米系统将是一个有前途的治疗策略，在OA治疗，由于其独特的特点是敏感的内部环境的变化。
Abstract Osteoarthritis (OA) is an inflammatory and degenerative joint disease with severe effects on individuals, society, and the economy that affects millions of elderly people around the world. To date, there are no effective treatments for OA; however, there are some treatments that slow or prevent its progression. Polyfunctional nanosystems have many advantages, such as controlled release, targeted therapy and high loading rate, and have been widely used in OA treatment. Previous mechanistic studies have revealed that inflammation and ROS are interrelated, and a large number of studies have demonstrated that ROS play an important role in different types of OA development. In this review article, we summarize third-generation ROS-sensitive nanomaterials that scavenge excessive ROS from chondrocytes and osteoclasts in vivo. We only focus on polymer-based nanoparticles (NPs) and do not review the effects of drug-loaded or heavy metal NPs. Mounting evidence suggests that polyfunctional nanosystems will be a promising therapeutic strategy in OA therapy due to their unique characteristics of being sensitive to changes in the internal environment.