Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans.
Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans.
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DOI：
10.1155/2014/267497
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发表时间：
2014-01-01
影响因子：
3.4
通讯作者：
Mora-Montes, Hector M
中科院分区：
文献类型：
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作者：
Martinez-Duncker, Ivan;Diaz-Jimenez, Diana F;Mora-Montes, Hector M
蛋白质糖化途径存在于所有生命王国中，也是存在于所有生命王国中的代谢途径。尽管它们在合成上有共同之处，但附着在糖蛋白上的多糖具有物种特有的结构，这些结构是由每个生物体中存在的不同组酶和受体底物产生的。在这篇综述中，我们对人类和白色念珠菌共有的主要糖基化途径进行了比较分析：N-连接糖基化、O-连接甘露糖化和糖基化磷脂酰肌醇-锚定。了解这些代谢途径之间的相似和差异可能有助于找到治疗白色念珠菌感染的新的药理靶点。
Protein glycosylation pathways are present in all kingdoms of life and are metabolic pathways found in all the life kingdoms. Despite sharing commonalities in their synthesis, glycans attached to glycoproteins have species-specific structures generated by the presence of different sets of enzymes and acceptor substrates in each organism. In this review, we present a comparative analysis of the main glycosylation pathways shared by humans and the fungal pathogen Candida albicans: N-linked glycosylation, O-linked mannosylation and glycosylphosphatidylinositol-anchorage. The knowledge of similarities and divergences between these metabolic pathways could help find new pharmacological targets for C. albicans infection.