IPSE/alpha-1:: A major immunogenic component secreted from Schistosoma mansoni eggs
IPSE/alpha-1:: A major immunogenic component secreted from Schistosoma mansoni eggs
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DOI：
10.1016/j.molbiopara.2006.01.003
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发表时间：
2006-05-01
影响因子：
1.5
通讯作者：
Doenhoff, MJ
中科院分区：
文献类型：
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作者：
Schramm, G;Gronow, A;Doenhoff, MJ
在感染曼氏血吸虫的过程中，这种寄生虫的卵阶段将初始的辅助性T细胞（Th 1）反应调节为Th 2反应。这表明，受精卵含有导致这种效应的因素。我们最近描述了一个糖蛋白（IPSE）从S。对人类嗜碱性粒细胞具有强效IL-4诱导作用的曼氏卵。在这里，我们证明了IPSE是相同的，以前描述的分子，S。曼氏卵抗原α-1我们还表明，IPSE/α-1在mRNA和蛋白质水平上的表达仅限于卵期。IPSE/α-1在蛋的亚壳区域产生并从该区域释放，并与聚集到蛋表面附近的炎性细胞密切接触。IPSE/alpha-1是三大S之一。曼氏卵糖蛋白，诱导明显的抗体反应。此外，其IL-4诱导能力表明fPSE/α-1在启动由专利S诱导的Th 2应答中起作用。曼氏感染。(c)2006 Elsevier B. V.保留所有权利。
During infection with Schistosoma mansoni the egg stage of this parasite modulates the initial T helper (Th1) response into a Th2 response. This suggests that schistosome eggs contain factors responsible for that effect. We have recently described a glycoprotein (IPSE) from S. mansoni eggs that has a potent IL-4-inducing effect on human basophils. Here we demonstrate that IPSE is identical to a previously described molecule, the S. mansoni egg antigen alpha-1. We furthermore show that the expression of IPSE/alpha-1 at the level of both mRNA and protein is restricted to the egg stage. IPSE/alpha-1 is produced in and released from the subshell area of the egg and comes into close contact with inflammatory cells recruited to the vicinity of the egg surface. In line with this IPSE/alpha-1 is one of three major S. mansoni egg glycoproteins that induce pronounced antibody responses. Its IL-4-inducing capacity, moreover, suggests that fPSE/alpha-1 plays a role in initiating the Th2 response induced by patent S. mansoni infections. (c) 2006 Elsevier B.V. All rights reserved.