Body weight and body water in chronic cor pulmonale.
Body weight and body water in chronic cor pulmonale.
复制标题
慢性肺心病的体重和体内水分。
DOI：
10.1042/cs0490323
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
P. Howard
中科院分区：
文献类型：
--
作者：
R. H. A. Campbell;H. L. Brand;J. R. Cox;P. Howard
1.对17例伴有慢性支气管炎和缺氧的水肿患者连续40次进行体重测量。所有患者当时都在服用利尿剂。2.随着外周水肿和颈静脉压升高，体重增加很少。治疗期间随后的体重减轻通常大于治疗前的体重增加。恢复期体重缓慢增加至等于或超过入院体重，一般健康状况未恶化或再次出现水肿。3.在急性病治疗和水肿清除后，对患者进行了全身水、交换性钠和交换性钾的测定，并在2-3个月后对6例患者进行了恢复期测定。总交换性钠是正常的或略有减少后，治疗水肿和恢复期之间复发的急性疾病。即使出现严重水肿，在此阶段研究的三名患者中只有一名患者的可交换钠大幅增加。总交换性钾总是受到严重抑制。4.在交换性钠没有可比变化的情况下，身体组织重量的巨大变化支持了先前的证据，即缺氧性支气管炎的水肿不仅仅是充血性心力衰竭的进一步形式。5.这表明，急性加重中至少有一些组织损失是低氧血症的直接结果，与在高海拔地区观察到的情况相似。部分水肿液被认为来源于组织基质溶解期间释放的细胞内水。
1. Body weight was measured through forty consecutive illnesses in seventeen patients with oedema in association with chronic bronchitis and hypoxia. All patients were taking diuretic drugs at the time. 2. Body weight increased little as peripheral oedema and a raised jugular venous pressure appeared. The subsequent weight-loss during treatment was usually greater than the pre-treatment weight-gain. Body weight increased slowly in convalescence to equal or exceed hospital admission weight without a deterioration of general health or reappearance of oedema. 3. Total body water, exchangeable sodium and exchangeable potassium were measured in patients after treatment of the acute illness and clearance of oedema and again in six patients of the group 2-3 months later in convalescence. Total exchangeable sodium was normal or slightly reduced after treatment of oedema and in convalescence between recurrent acute illnesses. Even when gross oedema was present exchangeable sodium was substantially increased in only one of three patients studied at this stage. Total exchangeable potassium was invariably severely depressed. 4. Large changes of body tissue weight without comparable change in exchangeable sodium support previous evidence that oedema in hypoxic bronchitis is not simply a further form of congestive cardiac failure. 5. It is suggested that at least some of the tissue loss in acute exacerbations is a direct result of hypoxaemia and similar to that observed at high altitude. Part of the oedema fluid is thought to be derived from intracellular water released during dissolution of tissue matrix.