Influence of material property variability on the mechanical behaviour of carotid atherosclerotic plaques: a 3D fluid-structure interaction analysis.
Influence of material property variability on the mechanical behaviour of carotid atherosclerotic plaques: a 3D fluid-structure interaction analysis.
复制标题
材料特性变异性对颈动脉粥样硬化斑块机械行为的影响：3D 流固相互作用分析。
DOI：
10.1002/cnm.2722
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发表时间：
2015-08
影响因子：
2.1
通讯作者：
Lu Q
中科院分区：
文献类型：
--
作者：
Yuan J;Teng Z;Feng J;Zhang Y;Brown AJ;Gillard JH;Jing Z;Lu Q
在评估动脉粥样硬化斑块易损性时，力学分析已被证明是管腔狭窄的补充。然而，患者特异性材料特性不可用，材料特性变异性的影响尚未完全量化。从颈动脉内膜切除术样本的介质和纤维帽（FC）条分为硬，中间和软，根据其增量杨氏模量。将脂质和斑块内出血/血栓条分为硬条和软条。进行了基于理想几何的3D流体-结构相互作用分析，以评估材料特性变化对预测最大主应力（Stress-P1）和拉伸（Stretch-P1）的影响。当FC较厚（1000或600 µm）时，肩部的应力-P1对材料刚度的变化不敏感，而中部FC的应力-P1变化显著。当FC较薄（200或65 μm）时，高应力集中从肩部区域转移到FC中部，应力-P1对材料特性的变化变得越来越敏感，特别是在FC中部。无论FC厚度如何，这些位置的Stretch-P1对材料特性的变化都很敏感。组织材料特性的变异性影响位置和总体应力/拉伸值。在解释力学模型的结果时，需要考虑这种可变性。© 2015作者。International Journal for Numerical Methods in Biomedical Engineering（International Journal for Numerical Methods in Biomedical Engineering，John Wiley & Sons Ltd.）
Mechanical analysis has been shown to be complementary to luminal stenosis in assessing atherosclerotic plaque vulnerability. However, patient-specific material properties are not available and the effect of material properties variability has not been fully quantified. Media and fibrous cap (FC) strips from carotid endarterectomy samples were classified into hard, intermediate and soft according to their incremental Young's modulus. Lipid and intraplaque haemorrhage/thrombus strips were classified as hard and soft. Idealised geometry-based 3D fluid-structure interaction analyses were performed to assess the impact of material property variability in predicting maximum principal stress (Stress-P1) and stretch (Stretch-P1). When FC was thick (1000 or 600 µm), Stress-P1 at the shoulder was insensitive to changes in material stiffness, whereas Stress-P1 at mid FC changed significantly. When FC was thin (200 or 65 µm), high stress concentrations shifted from the shoulder region to mid FC, and Stress-P1 became increasingly sensitive to changes in material properties, in particular at mid FC. Regardless of FC thickness, Stretch-P1 at these locations was sensitive to changes in material properties. Variability in tissue material properties influences both the location and overall stress/stretch value. This variability needs to be accounted for when interpreting the results of mechanical modelling. © 2015 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.