Classical nictitating membrane conditioning in rabbits with varying interstimulus intervals and direct activation of cerebellar mossy fibers as the CS.
Classical nictitating membrane conditioning in rabbits with varying interstimulus intervals and direct activation of cerebellar mossy fibers as the CS.
复制标题
兔子的经典瞬膜调节具有不同的刺激间隔和小脑苔藓纤维的直接激活作为 CS。
DOI：
10.1016/0166-4328(90)90008-3
复制
发表时间：
1990
影响因子：
2.7
通讯作者：
Steinmetz,JE
中科院分区：
文献类型：
--
作者：
Steinmetz,JE
用6个刺激间期(ISIS)研究了桥核条件刺激(CS)和非条件气泡刺激(US)在兔经典瞬膜(NM)/眼皮条件化(NM)/眼睑条件化(US)中的作用。类似于早期使用外周条件反射的研究，产生了一个将ISI和条件反射联系起来的倒U形函数。250毫秒和500毫秒的刺激间隔产生最高水平的条件反射，100、1000和2000毫秒的ISI导致较低的条件反射水平，而50毫秒的ISI则没有建立条件反射。这些结果表明，用直接激活小脑苔藓纤维代替传统的外周CS可以建立正常的ISI功能。
The rate and level of classical nictitating membrane (NM)/eyelid conditioning in rabbits established by pairing a pontine nucleus stimulation conditioned stimulus (CS) with an air puff unconditioned stimulus (US) were studied at 6 interstimulus intervals (ISIs). Similar to earlier studies which used peripheral CSs, an inverted U-shaped function relating ISI and conditioning was generated. Interstimulus intervals of 250 and 500 ms produced the highest levels of conditioning, 100, 1000 and 2000 ms ISIs resulted in lower levels of conditioning, and no conditioning was established with a 50 ms ISI. These results demonstrate that a normal ISI function can be established when direct activation of cerebellar mossy fibers is used as a CS instead of conventional peripheral CSs.