Prevalence and predictors of carotid wall triple line pattern in a general population sample.
Prevalence and predictors of carotid wall triple line pattern in a general population sample.
复制标题
一般人群样本中颈动脉壁三线模式的患病率和预测因素。
DOI：
10.1161/atvbaha.110.218057
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Bobak,Martin
中科院分区：
文献类型：
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作者：
Ryabikov,Andrew;Malyutina,Sofia;Halcox,Julian;Nikitin,Yuri;Marmot,Michael;Bobak,Martin
颈动脉内膜中层厚度（IMT）和斑块是动脉粥样硬化的标志物，可预测心血管事件。在不同的情况下，颈动脉壁的一种特殊的超声三线型（TLP）已被确定，但其起源和临床意义尚不清楚。我们研究了TLP的患病率和预测在一般population.Methods和ResultsThe研究进行了随机抽样的一般人群的新西伯利亚，俄罗斯，在国际健康，酒精和心理社会因素在东欧项目。在418名男性（年龄45至69岁）的子样本中，通过超声评估颈动脉IMT、动脉粥样硬化斑块的存在和TLP的存在。TLP的患病率为21%。与IMT（OR =9.53/1 SD，P<0.001）和斑块（OR = 2.42，P =0.002）相关。多变量模型中的其他预测因素包括年龄、收缩压、总胆固醇和吸烟。此外，不经常消费大量的酒精约增加了一倍的风险，三重pattern.ConclusionOur的研究结果显示高患病率的TLP颈动脉壁的一般男性人群样本，从一个典型的俄罗斯城市。这种超声模式与心血管危险因素和疾病、动脉粥样硬化的生物成像指标和间歇性大量饮酒密切相关。
ObjectiveCarotid intima-media thickness (IMT) and plaques are markers of atherosclerosis and predict cardiovascular events. A specific sonographic triple line pattern (TLP) of the carotid wall has been identified in different conditions, but its origin and clinical significance are unclear. We examined the prevalence and predictors of TLP in a general population.Methods and ResultsThe study was conducted in random sample of the general population of Novosibirsk, Russia, within the international Health, Alcohol and Psychosocial Factors in Eastern Europe project. In a subsample of 418 men (aged 45 to 69), carotid IMT, the presence of atherosclerotic plaques, and the presence of TLP were assessed by ultrasound. The prevalence of TLP was 21%. It was associated with IMT (odds ratio=9.53 per 1 SD,P<0.001) and the presence of plaques (odds ratio=2.42,P=0.002). Other predictors of TLP in multivariate models included age, systolic blood pressure, total cholesterol, and smoking. In addition, infrequent consumption of high amounts of alcohol approximately doubled the risk of triple pattern.ConclusionOur findings showed high prevalence of TLP of carotid wall in a general male population sample from a typical Russian city. This sonographic pattern was strongly associated with cardiovascular risk factors and diseases, bioimaging indicators of atherosclerosis, and episodic heavy drinking.