Molecular profiling of marine fauna: Integration of omics with environmental assessment of the world's oceans
Molecular profiling of marine fauna: Integration of omics with environmental assessment of the world's oceans
复制标题
DOI：
10.1016/j.ecoenv.2011.10.005
复制
发表时间：
2012-02-01
影响因子：
6.8
通讯作者：
Helbing, Caren C.
中科院分区：
文献类型：
--
作者：
Veldhoen, Nik;Ikonomou, Michael G.;Helbing, Caren C.
许多为我们海洋生态系统的商业和生态丰富性作出贡献的物种是环境变化的预兆。生物体能够迅速发现周围环境的变化并作出反应，这是对海洋哨兵物种应用分子特征分析技术的基础，目的是确定可能存在于转录组、蛋白质组或代谢组中并表明特定环境暴露事件的特征特征谱。目前的审查突出了海洋哨兵硬骨鱼，哺乳动物和无脊椎动物的生物信息的最新例子。虽然尚处于初期阶段，但这些基本信息可以为检测和评价环境化学污染物对海洋动物的影响提供一个系统生物学框架。在不同季节和当地海洋环境中反复进行评价，将有助于区分在引发特定哨兵鱼种生物反应的复杂环境因素中代表正常变异的特征谱，并有助于更好地了解生物途径的正常调节和与致癌相关的调节，这些调节已证明对海洋动物群有害。预计将污染物特异性分子特征纳入当前的风险评估范式将有助于加强野生动物管理策略，最大限度地减少工业化社会对海洋生态系统的影响。(C)2011 Elsevier Inc. All rights reserved.
Many species that contribute to the commercial and ecological richness of our marine ecosystems are harbingers of environmental change. The ability of organisms to rapidly detect and respond to changes in the surrounding environment represents the foundation for application of molecular profiling technologies towards marine sentinel species in an attempt to identify signature profiles that may reside within the transcriptome, proteome, or metabolome and that are indicative of a particular environmental exposure event. The current review highlights recent examples of the biological information obtained for marine sentinel teleosts, mammals, and invertebrates. While in its infancy, such basal information can provide a systems biology framework in the detection and evaluation of environmental chemical contaminant effects on marine fauna. Repeated evaluation across different seasons and local marine environs will lead to discrimination between signature profiles representing normal variation within the complex milieu of environmental factors that trigger biological response in a given sentinel species and permit a greater understanding of normal versus anthropogenic-associated modulation of biological pathways, which prove detrimental to marine fauna. It is anticipated that incorporation of contaminant-specific molecular signatures into current risk assessment paradigms will lead to enhanced wildlife management strategies that minimize the impacts of our industrialized society on marine ecosystems. (C) 2011 Elsevier Inc. All rights reserved.