Vasopressin increases urinary albumin excretion in rats and humans:: involvement of V2 receptors and the renin-angiotensin system
Vasopressin increases urinary albumin excretion in rats and humans:: involvement of V2 receptors and the renin-angiotensin system
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DOI：
10.1093/ndt/18.3.497
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发表时间：
2003-03-01
影响因子：
6.1
通讯作者：
Bankir, L
中科院分区：
文献类型：
--
作者：
Bardoux, P;Bichet, DG;Bankir, L
背景尿白蛋白排泄（UAE）增加是糖尿病（DM）肾小球损害的早期预测因子，也是高血压心血管并发症的危险因素。加压素在糖尿病和某些形式的高血压中升高。以前在大鼠中的研究表明，这种激素可以在慢性肾衰竭或糖尿病肾病中观察到的蛋白尿中发挥作用，但没有关于这些作用的机制以及加压素对健康肾脏中UAE的可能影响的信息。因此，本研究旨在评估加压素是否影响正常大鼠和人类的UAE，这种作用是否是V（2）受体依赖性的，以及是否由肾素-血管紧张素系统介导。在急性或慢性输注血管加压素V（2）受体激动剂dDAVP（R）之前和之后，对正常Wistar大鼠和健康人或患有各种形式尿崩症（DI）的受试者进行UAE测量。在之前接受慢性血管紧张素转换酶抑制（ACEI）或慢性AT 1受体阻断（ARB）的正常Wistar大鼠中也进行了慢性dDAVP给药。在大鼠中，急性或慢性dDAVP输注显著且可逆地增加UAE（分别为4倍和6倍）。在健康受试者中，急性输注dDAVP使UAE增加3倍（P
Background. An increase in urinary albumin excretion (UAE) represents an early predictor of glomerular damage in diabetes mellitus (DM) and a risk factor for cardiovascular complications in hypertension. Vasopressin is elevated in DM and in some forms of hypertension. Previous studies in rats suggested that this hormone could play a role in the albuminuria observed in chronic renal failure or diabetic nephropathy, but no information is available concerning the mechanism of these effects and the possible influence of vasopressin on UAE in the healthy kidney. The present study was thus designed to evaluate whether vasopressin influences UAE in normal rats and humans, whether this effect is V(2)-receptor-dependent, and whether it is mediated by the renin-angiotensin system.Methods. UAE was measured in normal Wistar rats and healthy humans, or in subjects with various forms of diabetes insipidus (DI), before and after acute or chronic infusion of the vasopressin V(2) receptor agonist dDAVP(R). Chronic dDAVP administration was also performed in normal Wistar rats previously submitted to either chronic angiotensin-converting enzyme inhibition (ACEI) or chronic blockade of AT1 receptors (ARB).Results. In rats, acute or chronic dDAVP infusion increased UAE significantly and reversibly (4-fold and 6-fold, respectively). In healthy subjects, acute infusion of dDAVP tripled UAE (P