Links between depression and substance abuse in adolescents - Neurobiological mechanisms
Links between depression and substance abuse in adolescents - Neurobiological mechanisms
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DOI：
10.1016/j.amepre.2006.07.002
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发表时间：
2006-12-01
影响因子：
5.5
通讯作者：
Rao, Uma
中科院分区：
文献类型：
--
作者：
Rao, Uma
青春期是抑郁症和药物使用障碍的高危时期。这两种疾病经常同时发生在青少年中，并与显著的发病率和死亡率有关。鉴于与并存疾病相关的额外经济和心理社会负担，确定与其共同发生相关的风险因素具有重要的公共卫生意义。对成年动物和人类的研究表明，几种常见的神经生物学系统将抑郁和成瘾障碍联系在一起。鉴于这些系统在整个青春期和成年早期不断成熟，目前尚不清楚这些神经生物学过程如何影响这两种疾病的发展和进展。更好地了解青春期这些疾病的发病和病程的病理生理机制，将有助于制定更有效的预防和治疗策略，从而使这些青少年在成年后能够充分发挥他们的潜力。
Adolescence is a high-risk period for development of both depressive and substance use disorders. These two disorders frequently co-occur in adolescents and are associated with significant morbidity and mortality. Given the added economic and psychosocial burden associated with the comorbid condition, identification of risk factors associated with their co-occurrence is of great public health importance. Research with adult animals and humans has indicated several common neurobiological systems that link depressive and addictive disorders. Given the ongoing maturation of these systems throughout adolescence and early adult life, it is not clear how these neurobiological processes influence development and progression of both disorders. A better understanding of the pathophysiological mechanisms leading to the onset and course of these disorders during adolescence will be helpful in developing more effective preventive and treatment strategies, and thereby allow these youth to reach their full potential as adults.