Effect of ovariectomy and calcium deficiency on the ultrasound velocity, mineral density and strength in the rat femur
Effect of ovariectomy and calcium deficiency on the ultrasound velocity, mineral density and strength in the rat femur
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DOI：
10.1016/s0268-0033(98)00019-9
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发表时间：
1998-10-01
影响因子：
1.8
通讯作者：
Ziv, I
中科院分区：
文献类型：
--
作者：
Han, SM;Szarzanowicz, TE;Ziv, I
Objective.超声传导速度（UTV）和骨密度（BMD）可作为去卵巢大鼠骨质疏松长骨抗弯强度的预测指标。由于骨质疏松症引起的松质骨质量的变化已经有了很好的记录，但只有少数研究描述了长骨生物力学质量的非侵入性评估。将43只大鼠分为三组：卵巢切除和钙耗尽饮食，卵巢切除和标准饮食，和未处理的对照组。通过定量计算机断层扫描（QCT）对所有股骨进行扫描，以测量骨干中段的BMD和皮质尺寸。弯曲强度由最大弯曲力矩和骨干中部的股骨皮质尺寸确定。测量股骨中段骨皮质骨近/远侧UTV。结果表明，各组间抗弯强度差异有显著性（P <0.05），
Objective. Ultrasound transmission velocity (UTV) and bone mineral density (BMD) were examined as possible predictors of the bending strength of osteoporotic long bones in ovariectomized rats treated with calcium-depleted diet.Background. Changes in cancellous bone quality due to osteoporosis have been well documented, but only a few studies described non-invasive assessment of the biomechanical quality of long bones.Methods. Forty-three rats were divided into three groups: ovariectomized and calcium-depleted diet, ovariectomized and standard diet, and untreated controls. All femora were scanned by quantitative computed tomography (QCT) to measure BMD and cortical dimensions at the mid-diaphysis. Bending strength was determined from the maximum bending moment and the femoral cortical dimensions at the mid-diaphysis. The UTV of cortical bond at the mid-disphysis of the femur was measured in the proximal/distal direction.Results. It was found that bending strength was significantly different among the groups (p