STRESS, ENDOGENOUS OPIOIDS AND SALT INTAKE
STRESS, ENDOGENOUS OPIOIDS AND SALT INTAKE
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DOI：
10.1016/s0195-6663(84)80050-1
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发表时间：
1984-01-01
期刊：
影响因子：
5.4
通讯作者：
YIM, GKW
中科院分区：
文献类型：
--
作者：
KUTA, CC;BRYANT, HU;YIM, GKW
The effect of stress on NaCl intake was examined in mice given a choice of water and 1·5% NaCl to drink. Immobilization of mice for 15-min and 24-h food deprivation resulted in a 2·5- and 5-fold increases in NaCl intake, respectively, without affecting water intake. Naloxone treatment (0·01, 0·1 and 1·0 mg/kg) produced a dose-dependent decrease in the stress-induced NaCl intake, as did Captopril treatment (5, 10 and 50 mg/kg). Intraventricular injection of angiotensin II in mice resulted in an increase in 1·5% NaCl intake, which was blocked by naloxone. Morphine (10 mg/kg) increased the preference of mice for a normally aversive 3·0% NaCl solution, but not for preferred, less concentrated, solutions of NaCl. The results suggest that both endogenous opioids and angiotensin II contribute to stress-induced NaCl intake, and that endogenous opioids may also mediate the increase in NaCl intake, observed with angiotensin II.
