Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
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DOI：
10.1002/2211-5463.12820
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发表时间：
2020-02
期刊：
影响因子：
2.6
通讯作者：
Peipei Peng;Xiaojin Zhang;Tao Qi;Hao Cheng;Qiuyue Kong;Li Liu;Xiaofei Cao;Zhengnian Ding
中科院分区：
文献类型：
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作者：
Peipei Peng;Xiaojin Zhang;Tao Qi;Hao Cheng;Qiuyue Kong;Li Liu;Xiaofei Cao;Zhengnian Ding
肺癌是癌症相关死亡的主要原因，目前仍需要新的治疗方法来治疗这种恶性肿瘤。在这里，我们研究了α‐硫辛酸（LA），一种用于治疗人类糖尿病并发症的药物，对肺癌生长的影响。我们报道，LA限制了异种移植小鼠的肺癌生长，降低了肺癌A549细胞的活力。我们在人肺癌中观察到自噬激活，并报道了LA使A549细胞的自噬失活。此外，LA还激活了哺乳动物雷帕霉素靶蛋白(mTOR)/p70S6K信号通路。雷帕霉素抑制mTOR逆转了LA诱导的自噬失活，并消除了LA诱导的A549细胞活力的抑制。总之，数据表明，LA通过mTOR介导的自噬抑制发挥抗肺癌作用，因此LA可能具有治疗肺癌的潜力。
Lung cancer is the leading cause of cancer‐related death, and there remains a need for novel therapies for this malignancy. Here, we examined the effects of alpha‐lipoic acid (LA), a drug used for treating human diabetic complications, on lung cancer growth. We report that LA limited lung cancer growth in xenograft mice and reduced lung cancer A549 cell viability. We observed autophagy activation in human lung cancers, and report that LA inactivated autophagy in A549 cells. In addition, LA activated mammalian target of rapamycin (mTOR)/p70S6K signaling. Inhibition of mTOR with rapamycin reversed LA‐induced inactivation of autophagy and abolished LA‐induced suppression of A549 cell viability. Altogether, the data suggest that LA exerts an anti‐lung cancer effect through mTOR‐mediated inhibition of autophagy, and thus LA may have therapeutic potential for lung cancer management.