Bone turnover markers and bone mineral density in children with haemophilia
Bone turnover markers and bone mineral density in children with haemophilia
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DOI：
10.1111/j.1365-2516.2010.02439.x
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发表时间：
2011-07-01
期刊：
影响因子：
3.9
通讯作者：
Orozco-Alcala, J.
中科院分区：
文献类型：
--
作者：
Tlacuilo-Parra, A.;Villela-Rodriguez, J.;Orozco-Alcala, J.
在儿童生长期间，骨经历涉及单独的成骨细胞和骨形成过程的建模。骨转换标志物在高浓度下循环，与儿童生长曲线平行，并与身高增长速度相关。本研究的目的是比较血友病和正常骨密度（BMD）与低BMD儿童的骨转换血清标志物。在一项横断面研究中，对69名血友病儿童进行了评估，其中45名儿童脊柱BMD正常，24名儿童BMD低。腰椎骨密度测定采用双能X线吸收法，并计算Z评分。采用ELISA法测定血清骨转换、骨钙素（骨形成）和I型胶原C端肽（骨吸收）标志物。正常组的平均骨密度（g cm（-2））为0.656 +/- 0.15，低骨密度组为0.558 +/- 0.12（P = 0.007），正常骨密度儿童的骨钙素水平为9.29 +/- 4.97，低骨密度组为7.06 +/- 2.17 ng mu L（-1）（P = 0.012）。正常组的C端肽水平为1.06 +/- 1.4，而低BMD组为0.74 +/- 0.3 ng/mL（-1）（P = 0.169）。我们的研究结果表明，低骨钙素水平在低BMD组中占主导地位，这表明成骨细胞骨形成活性降低，而骨吸收标志物无差异。此外，骨钙素水平解释了腰椎Z评分变化的10%。
During childhood growth, bone undergoes modelling involving separate osteoblastic and osteoclastic processes. Markers of bone turnover circulate at high concentrations, parallel the childhood growth curve and correlate with height velocity. The aim of this study was to compare serum markers of bone turnover in children with haemophilia and normal bone mineral density (BMD) vs. those with low BMD. In a cross-sectional study, 69 children with haemophilia were evaluated, 45 children with normal spine BMD vs. 24 with low BMD. Lumbar spine BMD was determined using dual X-ray absorptiometry and Z-scores were calculated. Serum samples of markers of bone turnover, osteocalcin (bone formation) and C-telopeptide of type I collagen (bone resorption) were measured using ELISA. The mean BMD (g cm(-2)) in the normal group was 0.656 +/- 0.15 vs. 0.558 +/- 0.12 in those with low BMD (P = 0.007), osteocalcin levels in children with normal BMD were 9.29 +/- 4.97 vs. 7.06 +/- 2.17 ng mu L(-1) in the low BMD group (P = 0.012). C-telopeptide levels in the normal group were 1.06 +/- 1.4 vs. 0.74 +/- 0.3 ng mL(-1) in the low BMD group (P = 0.169). Our results showed that low osteocalcin levels predominated in the group with low BMD, which indicates a diminished osteoblastic bone formation activity while there were no differences with regard to bone resorption markers. Moreover, osteocalcin levels explain 10% of the variation of lumbar spine Z-score.