IMPACT OF B SUBUNIT KILLED WHOLE-CELL AND KILLED WHOLE-CELL-ONLY ORAL VACCINES AGAINST CHOLERA UPON TREATED DIARRHOEAL ILLNESS AND MORTALITY IN AN AREA ENDEMIC FOR CHOLERA
IMPACT OF B SUBUNIT KILLED WHOLE-CELL AND KILLED WHOLE-CELL-ONLY ORAL VACCINES AGAINST CHOLERA UPON TREATED DIARRHOEAL ILLNESS AND MORTALITY IN AN AREA ENDEMIC FOR CHOLERA
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B 亚基灭活全细胞和灭活全细胞霍乱口服疫苗对霍乱流行地区治疗的腹泻病和死亡率的影响
DOI：
10.1016/s0140-6736(88)92189-7
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
J. Holmgren
中科院分区：
文献类型：
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作者：
J. Clemens;J. Harris;M. R. Khan;Mohammad Ali;M. Yunus;M. Khan;A. Svennerholm;D. Sack;J. Chakraborty;B. Stanton;F. Ahmed;B. Kay;M. Rao;J. Holmgren
在孟加拉国农村进行的一项随机双盲试验中，对B亚单位灭活全细胞（BS-WC）和仅灭活全细胞（WC）口服霍乱疫苗的影响进行了评估。62885名2-15岁的儿童和15岁以上的妇女服用了三剂一种疫苗或安慰剂。在随访的第一年，BS-WC组因治疗腹泻而就诊的次数减少了26%，WC组减少了22%。致死性或严重脱水腹泻的入院率在BS-WC组降低48%，在WC组降低33%。在第一年，BS-WC组的总死亡率降低了26%，WC组的总死亡率降低了23%，并且仅在15岁以上接种疫苗的妇女中观察到死亡率降低。然而，在监测的第二年结束时，累积死亡率没有明显的差异。
The impact of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind trial in rural Bangladesh. 62 285 children aged 2-15 years and women aged over 15 ingested three doses of one of the vaccines or placebo. During the first year of follow-up there was a 26% reduction of all visits for treatment of diarrhoea in the BS-WC group and a 22% reduction in the WC group. The reduction of all admissions for fatal or severely dehydrating diarrhoea was 48% in the BS-WC group and 33% in the WC group. Overall mortality rates were 26% lower in the BS-WC group and 23% lower in the WC group during the first year, and reductions of mortality were observed only in women vaccinated at ages over 15 years. However, no differences in cumulative mortality were evident at the end of the second year of surveillance.