A genetic framework for fruit patterning in Arabidopsis thaliana
A genetic framework for fruit patterning in Arabidopsis thaliana
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DOI：
10.1242/dev.02062
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发表时间：
2005-11-01
期刊：
影响因子：
4.6
通讯作者：
Yanofsky, MF
中科院分区：
文献类型：
--
作者：
Dinneny, JR;Weigel, D;Yanofsky, MF
在模式植物拟南芥（Arabidopsis thaliana）中，器官极性的建立导致FILAMENTOUS FLOWER （FIL）和YABBY3 （YAB3）在器官的一侧表达。一个重要的问题仍未得到解答，即这些位置信息如何导致控制组织身份的基因在空间上的正确激活？我们通过证明FIL和YAB3控制FRUITFULL （FUL）和SHATTERPROOF （SHP）的非重叠表达模式，提供了极性建立和组织特性调节之间的第一个功能联系，这两个基因是4687形成瓣缘组织条纹所必需的，这些条纹允许果实沿着两个确定的边界破碎并分散种子。FIL和YAB3通过JAGGED （JAG）冗余激活FUL和SHP， JAGGED是一种促进器官生长的基因，表明几种途径聚集在一起调节这些基因。这些活动受到REPLUMLESS （RPL）的负调控，它将FIL/JAG活动分开，形成两个不同的阀缘条纹。
In the model plant Arabidopsis thaliana, the establishment of organ polarity leads to the expression of FILAMENTOUS FLOWER (FIL) and YABBY3 (YAB3) on one side of an organ. One important question that has remained unanswered is how does this positional information lead to the correct spatial activation of genes controlling tissue identity? We provide the first functional link between polarity establishment and the regulation of tissue identity by showing that FIL and YAB3 control the non-overlapping expression patterns of FRUITFULL (FUL) and SHATTERPROOF (SHP), genes necessary to 4687 form stripes of valve margin tissue that allow the fruit to shatter along two defined borders and disperse the seeds. FIL and YAB3 activate FUL and SHP redundantly with JAGGED (JAG), a gene that also promotes growth in organs, indicating that several pathways converge to regulate these genes. These activities are negatively regulated by REPLUMLESS (RPL), which divides FIL/JAG activity, creating two distinct stripes of valve margin.