Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism.
Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism.
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DOI：
10.14348/molcells.2015.0167
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发表时间：
2015-09
影响因子：
3.8
通讯作者：
Haigis MC
中科院分区：
文献类型：
--
作者：
Jeong SM;Haigis MC
基因组不稳定性和代谢改变是大多数癌症的关键特征。最近的研究表明，代谢重编程是对细胞DNA损伤的系统反应的一部分。因此，定义响应DNA损伤微调代谢的分子将增强我们对肿瘤发生的分子机制的理解，并对癌症治疗策略的发展具有深远的意义。Sirtuins已被确立为细胞内稳态和生理学的关键调节剂。在这里，我们回顾了新出现的数据揭示了sirtuins在基因组维护和细胞代谢中的关键功能，并强调了目前的进展，这些关键调节因子在肿瘤发生中的缺陷的表型后果。虽然许多问题应该解决的调节和环境依赖性功能的sirtuins，它似乎很清楚，sirtuins可能会提供一个有前途的，令人兴奋的新途径的癌症治疗。
Genomic instability and altered metabolism are key features of most cancers. Recent studies suggest that metabolic reprogramming is part of a systematic response to cellular DNA damage. Thus, defining the molecules that fine-tune metabolism in response to DNA damage will enhance our understanding of molecular mechanisms of tumorigenesis and have profound implications for the development of strategies for cancer therapy. Sirtuins have been established as critical regulators in cellular homeostasis and physiology. Here, we review the emerging data revealing a pivotal function of sirtuins in genome maintenance and cell metabolism, and highlight current advances about the phenotypic consequences of defects in these critical regulators in tumorigenesis. While many questions should be addressed about the regulation and context-dependent functions of sirtuins, it appears clear that sirtuins may provide a promising, exciting new avenue for cancer therapy.