High educational performance is a distinctive feature of bipolar disorder: a study on cognition in bipolar disorder, schizophrenia patients, relatives and controls.
High educational performance is a distinctive feature of bipolar disorder: a study on cognition in bipolar disorder, schizophrenia patients, relatives and controls.
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DOI：
10.1017/s0033291715002299
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发表时间：
2016-03
影响因子：
6.9
通讯作者：
GROUP Investigators
中科院分区：
文献类型：
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作者：
Vreeker A;Boks MP;Abramovic L;Verkooijen S;van Bergen AH;Hillegers MH;Spijker AT;Hoencamp E;Regeer EJ;Riemersma-Van der Lek RF;Stevens AW;Schulte PF;Vonk R;Hoekstra R;van Beveren NJ;Kupka RW;Brouwer RM;Bearden CE;MacCabe JH;Ophoff RA;GROUP Investigators
精神分裂症与一般人群的智力低下和教育表现差有关。在精神分裂症患者的一级亲属中也发现了这种情况，但程度较轻。目前尚不清楚双相情感障碍I型（BD-I）患者及其亲属是否与精神分裂症患者一样，智力和教育表现较低。这项横断面研究调查了两个门诊样本（494名BD-I患者，952名精神分裂症谱系（SCZ）患者），2，231名BD-I和SCZ亲属患者，1，104名健康对照和100名对照兄弟姐妹的智力和教育表现。混合效应和回归模型被用来比较各组的智力和教育表现。尽管与对照组相比，BD-I患者的智商较低（β=-9.09，SE=1.27，p<0.001），但他们更有可能完成了最高水平的教育（OR=1.88 [1.66-2.70]）。相比之下，与对照组相比，SCZ患者表现出较低的智商（β=-15.31，SE=0.86，p<0.001）和较低的教育水平。两个患者组的sifiers有显着低于对照组的兄弟姐妹的智商，但没有不同的教育表现。智商得分没有显着差异，BD-I父母和SCZ父母，但BD-I父母完成了更高的教育水平。虽然BD-I患者的智商低于对照组，但他们更有可能完成了最高水平的教育。这与SCZ患者形成鲜明对比，与健康对照组相比，SCZ患者表现出智力和教育缺陷。由于BD-I患者的亲属没有表现出上级教育表现，我们的数据表明，高教育表现可能是双相情感障碍患者的一个显著特征。
Schizophrenia is associated with lower intelligence and poor educational performance relative to the general population. This is, to a lesser degree, also found in first-degree relatives of schizophrenia patients. It is unclear whether bipolar disorder I (BD-I) patients and their relatives have similar lower intellectual and educational performance as that observed in schizophrenia. This cross-sectional study investigated intelligence and educational performance in two outpatient samples (494 BD-I patients, 952 schizophrenia spectrum (SCZ) patients), 2,231 BD-I and SCZ relatives patients, 1,104 healthy controls and 100 control siblings. Mixed-effects- and regression models were used to compare groups on intelligence and educational performance. BD-I patients were more likely to have completed the highest level of education (OR=1.88 [1.66–2.70]) despite having a lower IQ compared with controls (β=−9.09, SE=1.27, p<0.001). In contrast, SCZ patients showed both a lower IQ (β= −15.31, SE=0.86, p<0.001) and lower educational levels compared with controls. Siblings of both patient groups had significantly lower IQ than control siblings, but did not differ on educational performance. IQ scores did not differ between BD-I parents and SCZ parents, but BD-I parents had completed higher educational levels. Although BD-I patients had a lower IQ than controls, they were more likely to have completed the highest level of education. This contrasts with SCZ patients, who showed both intellectual and educational deficits compared to healthy controls. Since relatives of BD-I patients did not demonstrate superior educational performance, our data suggest that high educational performance may be a distinctive feature of bipolar disorder patients.