Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D2 receptors
Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D2 receptors
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DOI：
10.1016/j.neuroimage.2017.06.066
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发表时间：
2017-09-01
期刊：
影响因子：
5.7
通讯作者：
Suhara, Tetsuya
中科院分区：
文献类型：
--
作者：
Ito, Hiroshi;Kawaguchi, Hiroshi;Suhara, Tetsuya
中枢多巴胺能系统在帕金森病、精神分裂症和其他神经精神障碍的病理生理学中具有重要意义。在本研究中，正常数据的多巴胺能神经传递功能的中脑，包括神经黑色素，多巴胺合成，多巴胺转运蛋白和多巴胺D-2受体，构建使用磁共振（MR）成像和正电子发射断层扫描（PET）。对健康年轻男性进行了L-[beta-C-11] DOPA、[F-18] FE-PE 2 I和[C-11] FLB 457的PET研究和MRI研究。通过MRI测量的神经黑色素积聚与通过PET测量的黑质中的多巴胺能功能、多巴胺合成能力、多巴胺转运蛋白结合和多巴胺D-2受体结合进行比较。虽然神经黑色素是由多巴胺能神经元中的多巴和多巴胺合成的，但在年轻健康受试者中，神经黑色素积累与多巴胺合成能力无关。多巴胺转运蛋白在黑质中的作用被认为是将多巴胺转运到神经元中，因此多巴胺转运蛋白结合可能与神经黑色素积累有关;然而，未观察到它们之间的显著相关性。观察到多巴胺D2受体结合和神经黑色素积累之间的正相关性，表明多巴胺能自身受体的反馈机制。在黑质中观察到神经黑素积聚与多巴胺合成能力、多巴胺转运体结合或多巴胺D-2受体结合之间的区域分布不一致。
The central dopaminergic system is of major importance in the pathophysiology of Parkinson's disease, schizophrenia, and other neuropsychiatric disorders. In the present study, the normative data of dopaminergic neurotransmission functions in the midbrain, consisting of neuromelanin, dopamine synthesis, dopamine transporters and dopamine D-2 receptors, were constructed using magnetic resonance (MR) imaging and positron emission tomography (PET). PET studies with L-[beta-C-11] DOPA, [F-18] FE-PE2I and [C-11] FLB457 and MRI studies were performed on healthy young men. Neuromelanin accumulation measured by MRI was compared with dopaminergic functions, dopamine synthesis capacity, dopamine transporter binding and dopamine D-2 receptor binding measured by PET in the substantia nigra. Although neuromelanin is synthesized from DOPA and dopamine in dopaminergic neurons, neuromelanin accumulation did not correlate with dopamine synthesis capacity in young healthy subjects. The role of dopamine transporters in the substantia nigra is considered to be the transport of dopamine into neurons, and therefore dopamine transporter binding might be related to neuromelanin accumulation; however, no significant correlation was observed between them. A positive correlation between dopamine D2 receptor binding and neuromelanin accumulation was observed, indicating a feedback mechanism by dopaminergic autoreceptors. Discrepancies in regional distribution between neuromelanin accumulation and dopamine synthesis capacity, dopamine transporter binding or dopamine D-2 receptor binding were observed in the substantia nigra.